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. 2023 Apr 11;85(5):2046-2048.
doi: 10.1097/MS9.0000000000000540. eCollection 2023 May.

Antineuronal autoantibodies induced paraneoplasic syndrome in schizophrenia spectrum disorders: case report

Fares Jaballah  1 , Nouha Ben Hamed  1 , Sayma Hamzaoui  1 , Mohamed A Ayadi  2 , Yosra Zgueb  1 , Rabaa Jomli  1
Affiliations

Antineuronal autoantibodies induced paraneoplasic syndrome in schizophrenia spectrum disorders: case report

Fares Jaballah et al. Ann Med Surg (Lond). .

Abstract

Secondary psychiatric symptoms are usually suspected when there is an atypical presentation of the symptoms or a lack of response to psychotropic medication.

Case presentation: Our case is about a woman aged 62 years old, with a history of mental disorder who presented psychiatric symptomatology after years of being stabilized by antipsychotics. She was later investigated due to a mass in her breast. Carcinoma was diagnosed, and her psychiatric symptomatology was resolved after the tumerectomy.

Discussion: The therapeutic difficulty is the major problem of psychic disorders in the context of paraneoplastic syndrome. Several literature review have suggested a relationship between schizophrenia and antineuronal antibodies in the context of paraneoplastic syndrome. Treating the tumor can solve psychiatric symptoms better than psychotic treatment.

Conclusions: The aim of our study is to highlight the importance of a complete medical evaluation to identify the psychiatric presentations of organic disorders associated with psychiatric manifestation and to ensure an early diagnosis.

Keywords: antineuronal antibodies; antirecoverin; case report; paraneoplastic syndrome; schizophrenia.

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Conflict of interest statement

The authors declare that they have no financial conflict of interest with regard to the content of this report.

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