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. 2023 Apr 17;85(5):1430-1435.
doi: 10.1097/MS9.0000000000000673. eCollection 2023 May.

Blood flow restricted walking in patients suffering from intermittent claudication: a case series feasibility and safety study

Andreas Bentzen  1 , Line B Nisgaard  1 , Rikke B L Mikkelsen  2 , Annette Høgh  3 , Inger Mechlenburg  1 , Stian L Jørgensen  4   5   6
Affiliations

Blood flow restricted walking in patients suffering from intermittent claudication: a case series feasibility and safety study

Andreas Bentzen et al. Ann Med Surg (Lond). .

Abstract

To examine the feasibility and safety of blood flow restricted walking (BFR-W) in patients with intermittent claudication (IC). Moreover, to evaluate changes in objective performance-based and self-reported functioning following 12 weeks of BFR-W.

Materials and methods: Sixteen patients with IC were recruited from two departments of vascular surgery. The BFR-W programme implied the application of a pneumatic cuff around the proximal part of the affected limb at 60% limb occlusion pressure in five intervals of 2 min, four times per week for 12 weeks. Feasibility was evaluated by adherence and completion rates of the BFR-W programme. Safety was evaluated by adverse events, ankle-brachial index (ABI) at baseline and follow-up, and pain on a numerical rating scale (NRS pain) before and 2 min after training sessions. Furthermore, changes in performance between baseline and follow-up were evaluated with the 30 seconds sit-to-stand test (30STS), the 6-minute walk test (6MWT) and the IC questionnaire (ICQ).

Results: Fifteen out of 16 patients completed the 12-week BFR-W programme and adherence was 92.8% (95% CI: 83.4; 100%). One adverse event unrelated to the intervention was reported causing one patient to terminate the programme 2 weeks prematurely. Mean NRS pain 2 min following BFR-W was 1.8 (95% CI [1.7-2]). ABI, 30STS, 6MWT and ICQ score were improved at follow-up.

Conclusions: BFR-W is feasible and appears to be safe in terms of completion rate, adherence to the training protocol, and adverse events in patients with IC. Further investigation of the effectiveness and safety of BFR-W compared to regular walking exercise is needed.

Keywords: blood flow restricted walking; case series; conservative treatment; intermittent claudication; peripheral arterial diseases; walking exercise.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Flowchart of patient enrolment. *Other reasons: transportation time (n=4), limited time to participate (n=4), prioritised other disabilities (n=3) and not comfortable with BFR-W (n=1). BFR-W, blood flow restricted walking.
See this image and copyright information in PMC

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References

    1. Gerhard-Herman MD, Gornik HL, Barrett C, et al. . 2016 AHA/ACC Guideline on the management of patients with lower extremity peripheral artery disease: executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Circulation 2017;135:e686–e725. - PMC - PubMed
    1. Song P, Rudan D, Zhu Y, et al. . Global, regional, and national prevalence and risk factors for peripheral artery disease in 2015: an updated systematic review and analysis. Lancet Glob Health 2019;7:e1020–e30. - PubMed
    1. Cassar K. Intermittent claudication. BMJ 2006;333:1002–1005. - PMC - PubMed
    1. Hamburg NM, Creager MA. Pathophysiology of intermittent claudication in peripheral artery disease. Circ J 2017;81:281–289. - PubMed
    1. Hardman RL, Jazaeri O, Yi J, et al. . Overview of classification systems in peripheral artery disease. Semin Intervent Radiol 2014;31:378–388. - PMC - PubMed