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. 2023 Apr 12;85(5):2130-2134.
doi: 10.1097/MS9.0000000000000592. eCollection 2023 May.

Surgical management of giant recurrent retroperitoneal liposarcoma: a case report and review of the literature

Madani Ayoub  1   2 , Bouzayan Leila  1   2 , Mabrouk Yassin  1   2 , Miry Achraf  1   2 , Jabi Rachid  1   2 , Pr Bouziane Mohamed  1   2
Affiliations

Surgical management of giant recurrent retroperitoneal liposarcoma: a case report and review of the literature

Madani Ayoub et al. Ann Med Surg (Lond). .

Abstract

Liposarcoma is a rare, primary, malignant mesenchymal tumor. It represents ∼7% of all mesenchymal sarcomas and 1% of all cancers. Their incidence does not exceed to 2.5 cases/million inhabitants/year. This tumor is locally invasive, diagnosed at a late stage, and can reach a significant size and weight, resulting in a locally advanced tumor.

Case presentation: A 59-year-old female patient consulting for a large abdominal mass. The abdominal computed tomography showed three retroperitoneal masses, and the surgical exploration revealed a huge process in the retroperitoneal cavity, which takes the left renal compartment, and the left colon. The intervention consisted of a mono-bloc excision of the mass taking the spleen, the left renal compartment, and the left colon with colonic anastomosis. The histological examination concluded the existence of a well-differentiated myxoid liposarcoma of grade I, the postoperative follow-up was simple. One year later, she underwent an excision of a recurrence of the same retroperitoneal location, but of a pleomorphic cell histological type of grade II according to the FNCLCC classification. We review the literature, the pathological, therapeutic, and prognostic aspects of this tumor.

Discussion: Retroperitoneal liposarcoma is a rare tumor. Its gravity is due to an often-late diagnosis, a complete imaging workup including ultrasound, computed tomography and often MRI is necessary preoperatively to determine the relationship with the different organs. The definitive diagnosis is histological, surgery is the most effective treatment and can be extended to neighboring organs. the frequency of recurrence requires particular surveillance.

Conclusions: We highlight the importance of radical surgical excision to avoid retroperitoneal liposarcoma tumor complications and to minimize the recurrence risk.

Keywords: case report; giant masses; liposarcoma; myxoid cells; pleomorphic cells.

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Conflict of interest statement

The authors declare that they have no financial conflict of interest with regard to the content of this report.

Figures

Figure 1
Figure 1
Computed tomography images showing the tumors their boundaries and extensions.
Figure 2
Figure 2
Computed tomography images showing the tumors their boundaries and extensions.
Figure 3
Figure 3
Image of the surgical specimen after tumor resection in one piece.
Figure 4
Figure 4
Paucicellular proliferation, made of spindle-shaped cells arranged on a myxoid background (hematoxylin and eosin; ×100).
Figure 5
Figure 5
Image of the recurrence piece after resection.
Figure 6
Figure 6
Atypical appearance of tumor cells. It presents a nuclear pleomorphism, frequent multinucleations with numerous mitoses (hematoxylin and eosin; ×400).
See this image and copyright information in PMC

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