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Review
. 2023 Aug:164:114916.
doi: 10.1016/j.biopha.2023.114916. Epub 2023 May 23.

Advancing therapeutic strategies for Epstein-Barr virus-associated malignancies through lytic reactivation

Haiqi Tan  1 , Yibing Gong  1 , Yi Liu  1 , Jingyi Long  1 , Qingshuang Luo  1 , Oluwasijibomi Damola Faleti  2 , Xiaoming Lyu  3
Affiliations
Free article
Review

Advancing therapeutic strategies for Epstein-Barr virus-associated malignancies through lytic reactivation

Haiqi Tan et al. Biomed Pharmacother. 2023 Aug.
Free article

Abstract

Epstein-Barr virus (EBV) is a widespread human herpes virus associated with lymphomas and epithelial cell cancers. It establishes two separate infection phases, latent and lytic, in the host. Upon infection of a new host cell, the virus activates several pathways, to induce the expression of lytic EBV antigens and the production of infectious virus particles. Although the carcinogenic role of latent EBV infection has been established, recent research suggests that lytic reactivation also plays a significant role in carcinogenesis. In this review, we summarize the mechanism of EBV reactivation and recent findings about the role of viral lytic antigens in tumor formation. In addition, we discuss the treatment of EBV-associated tumors with lytic activators and the targets that may be therapeutically effective in the future.

Keywords: Carcinogenesis; EBV; Lytic reactivation; Therapies.

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Conflict of interest statement

Declaration of Competing Interest All authors of this paper have read and approved the final version submitted And the authors declare no conflict of interest The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.

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