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Observational Study
. 2023 Jul-Aug;75(4):243-250.
doi: 10.1016/j.ihj.2023.05.009. Epub 2023 May 23.

COVID-19 infected ST-Elevation myocardial infarction in India (COSTA INDIA)

Abdullakutty Jabir  1 , Geevar Zachariah  2 , Padinhare Purayil Mohanan  3 , Mohit Dayal Gupta  4 , Sivasubramanian Ramakrishnan  5 , Chandra Bhan Meena  6 , L Sridhar  7 , Meennahalli Palleda Girish  8 , Dipak Ranjan Das  9 , Anshul Gupta  10 , Praveen Nagula  11 , Tom Devasia  12 , Bhavesh Vajifdar  13 , Kamlesh Thakkar  14 , Urmil Shah  15 , Tanuj Bhatia  16 , Smit Srivastava  17 , Sanjeev Sharma  18 , Priya Kubendiran  19 , Pathiyil Balagopalan Jayagopal  20 , Sudeep Kumar  21 , Deepthy Sadanandan  22 , Lincy Mathew  23 , Nitish Naik  24 , Anup Banerji  25 , S M Ashraf  26 , P K Asokan  27 , Bishwa Bhushan Bharti  28 , Biswajit Majumder  29 , Dhiman Kahali  30 , Dhurjati Prasad Sinha  31 , Dipak Sharma  32 , Dipankar Ghosh Dastidar  33 , Dipankar Mukhapdhyay  34 , Gurpreet Sing Wander  35 , Harinder Kumar Bali  36 , B Kesavamoorthy  37 , Manoj Kumar Agarwala  38 , Narendra Nath Khanna  39 , B H Natesh  40 , Pravin K Goel  41 , Rabindra Nath Chakraborty  42 , Rajendra Kumar Jain  43 , Rakesh Yadav  44 , L Sameer Dani  45 , Satyavan Sharma  46 , Satyendra Tewari  47 , K K Sethi  48 , Sharad Chandra  49 , Subrato Mandal  50 , Suman Bhandari  51 , Sundandan Sikdar  52 , Vivek Gupta  53 , Pratap Chandra Rath  54 , Vijay Harikisan Bang  55 , Debabrata Roy  56 , Mrinal Kanti Das  57 , Partho Sarathi Banerjee  58
Affiliations
Observational Study

COVID-19 infected ST-Elevation myocardial infarction in India (COSTA INDIA)

Abdullakutty Jabir et al. Indian Heart J. 2023 Jul-Aug.

Abstract

Objective: To find out differences in the presentation, management and outcomes of COVID-19 infected STEMI patients compared to age and sex-matched non-infected STEMI patients treated during the same period.

Methods: This was a retrospective multicentre observational registry in which we collected data of COVID-19 positive STEMI patients from selected tertiary care hospitals across India. For every COVID-19 positive STEMI patient, two age and sex-matched COVID-19 negative STEMI patients were enrolled as control. The primary endpoint was a composite of in-hospital mortality, re-infarction, heart failure, and stroke.

Results: 410 COVID-19 positive STEMI cases were compared with 799 COVID-19 negative STEMI cases. The composite of death/reinfarction/stroke/heart failure was significantly higher among the COVID-19 positive STEMI patients compared with COVID-19 negative STEMI cases (27.1% vs 20.7% p value = 0.01); though mortality rate did not differ significantly (8.0% vs 5.8% p value = 0.13). Significantly lower proportion of COVID-19 positive STEMI patients received reperfusion treatment and primary PCI (60.7% vs 71.1% p value=< 0.001 and 15.4% vs 23.4% p value = 0.001 respectively). Rate of systematic early PCI (pharmaco-invasive treatment) was significantly lower in the COVID-19 positive group compared with COVID-19 negative group. There was no difference in the prevalence of high thrombus burden (14.5% and 12.0% p value = 0.55 among COVID-19 positive and negative patients respectively) CONCLUSIONS: In this large registry of STEMI patients, we did not find significant excess in in-hospital mortality among COVID-19 co-infected patients compared with non-infected patients despite lower rate of primary PCI and reperfusion treatment, though composite of in-hospital mortality, re-infarction, stroke and heart failure was higher.

Keywords: COVID positive STEMI; MI during COVID; STEMI and COVID; STEMI during COVID; STEMI management.

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Figures

Fig. 1
Fig. 1
Plot of adjusted Relative Risk (aRR) and 95% confidence intervals(CI) for factors associated with mortality obtained from multivariable Robust Poisson regression.
See this image and copyright information in PMC

References

    1. Garcia S., Dehghani P., Grines C., et al. Initial findings from the north American COVID-19 myocardial infarction registry. J Am Coll Cardiol. 2021 Apr 27;77(16):1994–2003. - PMC - PubMed
    1. De Luca G., Debel N., Cercek M., et al. Impact of SARS-CoV-2 positivity on clinical outcome among STEMI patients undergoing mechanical reperfusion: insights from the ISACS STEMI COVID- 19 registry. Atherosclerosis. 2021 Sep;332:48–54. - PMC - PubMed
    1. Kite T.A., Ludman P.F., Gale C.P., et al. International prospective registry of acute coronary syndromes in patients with COVID-19. J Am Coll Cardiol. 2021 May 25;77(20):2466–2476. - PMC - PubMed
    1. Hamadeh A., Aldujeli A., Briedis K., et al. Characteristics and outcomes in patients presenting with COVID-19 and ST-segment elevation myocardial infarction. Am J Cardiol. 2020 Sep 15;131:1–6. - PMC - PubMed
    1. Kunal S., Pathak V., Pathak K., Mishra M., Sharma S.M., Bhandari S. Very late stent thrombosis associated with COVID-19 infection: a case report and review of the literature. Monaldi Arch Chest Dis Arch Monaldi Mal Torace. 2021 Sep 16 - PubMed

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