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Case Reports
. 2023 May 25;23(1):355.
doi: 10.1186/s12879-023-08336-3.

First case of bloodstream infection caused by NDM-positive Escherichia hermannii

Bin Lu  1 , Bin Wang  2 , Xinling Pan  3 , Chenxin Liu  1 , Chenyuan Jin  1 , Yunzhen Shi  4 , Yangxiao Zhou  5
Affiliations
Case Reports

First case of bloodstream infection caused by NDM-positive Escherichia hermannii

Bin Lu et al. BMC Infect Dis. .

Abstract

Background: Escherichia hermannii (E. hermanni) is always accompanied by other bacterial infections in humans. In previous reports, most E. hermannii-related infections were caused by sensitive strains. Here, for the first time, we report the case of a patient with New Delhi metallo-β-lactamase (NDM)-positive E. hermannii bloodstream infection.

Case presentation: The patient was a 70-year-old male admitted to our hospital due to a 4-day fever, with a history of malignant tumor, liver cirrhosis, and chronic obstructive pulmonary disease. After admission, his blood culture tested positive for E. hermannii. The drug resistance analysis showed positive for NDM resistance, with susceptibility to aztreonam, levofloxacin, and amikacin. The blood culture turned negative after 8 days of aztreonam treatment. The patient's symptoms improved, and he was discharged after 14 days of hospitalization.

Conclusions: This is the first report of a bloodstream infection caused by an NDM-positive E. hermannii strain. The anti-infection regimen used in this case provides a new reference regimen for clinical practice.

Keywords: Aztreonam; Bloodstream infection; Escherichia hermannii; NDM-positive.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Identification of an NDM-positive Escherichia hermannii. (A) The colony morphology of Escherichia hermannii on the blood culture plate; (B) The enzymes for carbapenem resistance by gold immunolabeling test
Fig. 2
Fig. 2
The inflammatory indexes of this case infected by NDM-positive Escherichia hermannii during hospitalization
See this image and copyright information in PMC

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