Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Meta-Analysis
. 2023 May 25;12(1):57.
doi: 10.1186/s40249-023-01107-x.

Global prevalence of drug-resistant tuberculosis: a systematic review and meta-analysis

Nader Salari  1   2 , Amir Hossein Kanjoori  3 , Amin Hosseinian-Far  4 , Razie Hasheminezhad  3 , Kamran Mansouri  5 , Masoud Mohammadi  6
Affiliations
Meta-Analysis

Global prevalence of drug-resistant tuberculosis: a systematic review and meta-analysis

Nader Salari et al. Infect Dis Poverty. .

Abstract

Background: Tuberculosis is a bacterial infectious disease, which affects different parts of a human body, mainly lungs and can lead to the patient's death. The aim of this study is to investigate the global prevalence of drug-resistant tuberculosis using a systematic review and meta-analysis.

Methods: In this study, the PubMed, Scopus, Web of Science, Embase, ScienceDirect and Google Scholar repositories were systematically searched to find studies reporting the global prevalence of drug-resistant tuberculosis. The search did not entail a lower time limit, and articles published up until August 2022 were considered. Random effects model was used to perform the analysis. The heterogeneity of the studies was examined with the I2 test. Data analysis was conducted within the Comprehensive Meta-Analysis software.

Results: In the review of 148 studies with a sample size of 318,430 people, the I2 index showed high heterogeneity (I2 = 99.6), and accordingly random effects method was used to analyze the results. Publication bias was also examined using the Begg and Mazumdar correlation test which indicated the existence of publication bias in the studies (P = 0.008). According to our meta-analysis, the global pooled prevalence of multi-drug resistant TB is 11.6% (95% CI: 9.1-14.5%).

Conclusions: The global prevalence of drug-resistant tuberculosis was found to be very high, thus health authorities should consider ways to control and manage the disease to prevent a wider spread of tuberculosis and potentially subsequent deaths.

Keywords: Burden; Drug-resistant tuberculosis; Outbreak; Prevalence; TB.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1
PRISMA flow diagram for study selection
See this image and copyright information in PMC

References

    1. Iacobino A, Fattorini L, Giannoni F. Drug-resistant tuberculosis 2020: where we stand. Appl Sci. 2020;10(6):2153. doi: 10.3390/app10062153. - DOI
    1. Asgedom SW, Teweldemedhin M, Gebreyesus H. Prevalence of multidrug-resistant tuberculosis and associated factors in Ethiopia: a systematic review. J Pathogens. 2018;2018:7104921. doi: 10.1155/2018/7104921. - DOI - PMC - PubMed
    1. Lange C, Chesov D, Heyckendorf J, Leung CC, Udwadia Z, Dheda K. Drug-resistant tuberculosis: an update on disease burden, diagnosis and treatment. Respirology. 2018;23(7):656–673. doi: 10.1111/resp.13304. - DOI - PubMed
    1. Mazurek GH. Division of tuberculosis elimination, national center for HIV, STD, and TB prevention, centers for disease control and prevention (CDC). Guidelines for using the QuantiFERON-TB gold test for detecting Mycobacterium tuberculosis infection, United States. MMWR Recomm Rep. 2005;54:49–55. - PubMed
    1. Global Tuberculosis Report 2022. https://www.who.int/teams/global-tuberculosis-programme/tb-reports/globa....