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Review
. 2023 Apr-Jun;106(2):368504231175331.
doi: 10.1177/00368504231175331.

Advanced treatment strategies in breast cancer: A comprehensive mechanistic review

Samaira Mumtaz  1 , Shaukat Ali  1 , Shumaila Mumtaz  1 , Asim Pervaiz  2 , Hafiz M Tahir  1 , Muhammad A Farooq  1 , Tafail A Mughal  1
Affiliations
Review

Advanced treatment strategies in breast cancer: A comprehensive mechanistic review

Samaira Mumtaz et al. Sci Prog. 2023 Apr-Jun.

Abstract

Breast cancer is a destructive lump type that affects women globally. Despite the availability of multi-directional therapeutic strategies, advanced stages of breast cancer are difficult to treat and impose major healthcare burdens. This situation reinforces the need to identify new potential therapeutic compounds with better clinical features. In this context, different treatment methods were included such as Endocrine therapy, chemotherapy, Radiation therapy, antimicrobial peptide-dependent growth inhibitor, liposome-based drug delivery, antibiotics used as a co-medication, photothermal, immunotherapy, and nano drug delivery systems such as Bombyx mori natural protein sericin and its mediated nanoparticles are promising biomedical agents. They have been tested as an anticancer agent against various malignancies in pre-clinical settings. The biocompatible and restricted breakdown properties of silk sericin and sericin-conjugated nanoparticles made them perfect contenders for a nanoscale drug-delivery system.

Keywords: Breast cancer; breast malignancy growth pattern; molecular subtypes; prognosis; sericin.

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Conflict of interest statement

The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
Taxonomy of breast tumor.
Figure 2.
Figure 2.
Pathophysiology of breast cancer.
Figure 3.
Figure 3.
Mechanism action of Taxol.
Figure 4.
Figure 4.
Radiation therapy.
Figure 5.
Figure 5.
Role of metformin in the treatment of breast cancer (BC).
Figure 6.
Figure 6.
Antibody-dependent cell-mediated breast cancer (BC) therapy.
Figure 7.
Figure 7.
Breast cancer activity of Sericin nanoparticles (NPs).
See this image and copyright information in PMC

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