Polygenic Risk Scores: Genomes to Risk Prediction

Tristan J Hayeck^{1

2}, George B Busby³, Sung Chun^{4

5}, Anna C F Lewis⁶, Megan C Roberts⁷, Bjarni J Vilhjálmsson^{8

9

10}

Affiliations

¹ Assistant Professor, Division of Genomic Diagnostics, Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, United States.
² Assistant Professor, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.
³ Chief Scientific Officer, Allelica Inc., New York, NY, United States.
⁴ Scientist, Division of Pulmonary Medicine, Boston Children's Hospital, Boston, MA, United States.
⁵ Instructor of Pediatrics, Department of Pediatrics, Harvard Medical School, Boston, MA, United States.
⁶ Research Associate, Edmond and Lily Safra Center for Ethics, Harvard University, and Division of Genetics, Brigham and Women's Hospital, Boston, MA, United States.
⁷ Assistant Professor and Director Implementation Science, in Precision Health & Society, Division of Pharmaceutical Outcomes and Policy, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, United States.
⁸ Professor, National Centre for Register-based Research, Aarhus University, Aarhus, Denmark.
⁹ Professor, Bioinformatics Research Centre, Aarhus University, Aarhus, Denmark.
¹⁰ Professor, Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA, United States.

Tristan J Hayeck et al. Clin Chem. 2023.

. 2023 Jun 1;69(6):551-557.

doi: 10.1093/clinchem/hvad049.

Tristan J Hayeck^{1

2}, George B Busby³, Sung Chun^{4

5}, Anna C F Lewis⁶, Megan C Roberts⁷, Bjarni J Vilhjálmsson^{8

9

10}

¹ Assistant Professor, Division of Genomic Diagnostics, Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, United States.
² Assistant Professor, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.
³ Chief Scientific Officer, Allelica Inc., New York, NY, United States.
⁴ Scientist, Division of Pulmonary Medicine, Boston Children's Hospital, Boston, MA, United States.
⁵ Instructor of Pediatrics, Department of Pediatrics, Harvard Medical School, Boston, MA, United States.
⁶ Research Associate, Edmond and Lily Safra Center for Ethics, Harvard University, and Division of Genetics, Brigham and Women's Hospital, Boston, MA, United States.
⁷ Assistant Professor and Director Implementation Science, in Precision Health & Society, Division of Pharmaceutical Outcomes and Policy, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, United States.
⁸ Professor, National Centre for Register-based Research, Aarhus University, Aarhus, Denmark.
⁹ Professor, Bioinformatics Research Centre, Aarhus University, Aarhus, Denmark.
¹⁰ Professor, Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA, United States.

No abstract available

Conflict of interest statement

Authors’ Disclosures or Potential Conflicts of Interest: Upon manuscript submission, all authors completed the author disclosure form.