Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 May 13;30(5):4990-5002.
doi: 10.3390/curroncol30050377.

Surgical Management of Brain Tumors with Focused Ultrasound

Yusuf Mehkri  1 , Kevin Pierre  2 , Samuel Joel Woodford  1 , Caroline Grace Davidson  1 , Ogaga Urhie  1 , Sai Sriram  1 , Jairo Hernandez  1 , Chadwin Hanna  1 , Brandon Lucke-Wold  1
Affiliations
Review

Surgical Management of Brain Tumors with Focused Ultrasound

Yusuf Mehkri et al. Curr Oncol. .

Abstract

Focused ultrasound is a novel technique for the treatment of aggressive brain tumors that uses both mechanical and thermal mechanisms. This non-invasive technique can allow for both the thermal ablation of inoperable tumors and the delivery of chemotherapy and immunotherapy while minimizing the risk of infection and shortening the time to recovery. With recent advances, focused ultrasound has been increasingly effective for larger tumors without the need for a craniotomy and can be used with minimal surrounding soft tissue damage. Treatment efficacy is dependent on multiple variables, including blood-brain barrier permeability, patient anatomical features, and tumor-specific features. Currently, many clinical trials are currently underway for the treatment of non-neoplastic cranial pathologies and other non-cranial malignancies. In this article, we review the current state of surgical management of brain tumors using focused ultrasound.

Keywords: brain tumors; focused ultrasound; non-invasive therapy.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Considerations related to treatment success and failure in the use of FUS.
See this image and copyright information in PMC

References

    1. Quadri S.A., Waqas M., Khan I., Khan M.A., Suriya S.S., Farooqui M., Fiani B. High-intensity focused ultrasound: Past, present, and future in neurosurgery. Neurosurg. Focus. 2018;44:E16. doi: 10.3171/2017.11.FOCUS17610. - DOI - PubMed
    1. Krishna V., Sammartino F., Rezai A. A Review of the Current Therapies, Challenges, and Future Directions of Transcranial Focused Ultrasound Technology: Advances in Diagnosis and Treatment. JAMA Neurol. 2018;75:246–254. doi: 10.1001/jamaneurol.2017.3129. - DOI - PubMed
    1. Harary M., Segar D.J., Huang K.T., Tafel I.J., Valdes P.A., Cosgrove G.R. Focused ultrasound in neurosurgery: A historical perspective. Neurosurg. Focus. 2018;44:E2. doi: 10.3171/2017.11.FOCUS17586. - DOI - PubMed
    1. Jung N.Y., Chang J.W. Magnetic Resonance-Guided Focused Ultrasound in Neurosurgery: Taking Lessons from the Past to Inform the Future. J. Korean Med. Sci. 2018;33:e279. doi: 10.3346/jkms.2018.33.e279. - DOI - PMC - PubMed
    1. Phenix C.P., Togtema M., Pichardo S., Zehbe I., Curiel L. High intensity focused ultrasound technology, its scope and applications in therapy and drug delivery. J. Pharm. Pharm. Sci. 2014;17:136–153. doi: 10.18433/J3ZP5F. - DOI - PubMed

MeSH terms