Secreted Protein Acidic and Rich in Cysteine (SPARC) to Manage Coronavirus Disease-2019 (COVID-19) Pandemic and the Post-COVID-19 Health Crisis
- PMID: 37233608
- PMCID: PMC10220988
- DOI: 10.3390/medicines10050032
Secreted Protein Acidic and Rich in Cysteine (SPARC) to Manage Coronavirus Disease-2019 (COVID-19) Pandemic and the Post-COVID-19 Health Crisis
Abstract
Coronavirus disease-2019 (COVID-19) has had and will have impacts on public health and health system expenses. Indeed, not only it has led to high numbers of confirmed COVID-19 cases and hospitalizations, but its consequences will remain even after the end of the COVID-19 crisis. Therefore, therapeutic options are required to both tackle the COVID-19 crisis and manage its consequences during the post COVID-19 era. Secreted protein acidic and rich in cysteine (SPARC) is a biomolecule that is associated with various properties and functions that situate it as a candidate which may be used to prevent, treat and manage COVID-19 as well as the post-COVID-19-era health problems. This paper highlights how SPARC could be of such therapeutic use.
Keywords: coronavirus disease-2019 (COVID-19); potential therapies; secreted protein acidic and rich in cysteine (SPARC).
Conflict of interest statement
The authors declare that there are no conflict of interest.
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References
-
- Lüthy I.A., Ritacco V., Kantor I.N. One hundred years after the “Spanish” flu. Medicina. 2018;78:113–118. - PubMed
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