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. 1979 Jul;139(1):161-4.
doi: 10.1128/jb.139.1.161-164.1979.

Reduction of methionine sulfoxide to methionine by Escherichia coli

S I Ejiri, H Weissbach, N Brot

Reduction of methionine sulfoxide to methionine by Escherichia coli

S I Ejiri et al. J Bacteriol. 1979 Jul.

Abstract

L-Methionine-dl-sulfoxide can support the growth of an Escherichia coli methionine auxotroph, suggesting the presence of an enzyme(s) capable of reducing the sulfoxide to methionine. This was verified by showing that a cell-free extract of E. coli catalyzes the conversion of methionine sulfoxide to methionine. This reaction required reduced nicotinamide adenine dinucleotide phosphate and a generating system for this compound. The specific activity of the enzyme increased during logarithmic growth and was maximal when the culture attained a density of about 10(9) cells per ml.

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References

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