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Review
. 2023 May 10:14:1195272.
doi: 10.3389/fphys.2023.1195272. eCollection 2023.

Skin aging from mechanisms to interventions: focusing on dermal aging

Sun Hye Shin  1 , Yoon Hwan Lee  1 , Nark-Kyoung Rho  2 , Kui Young Park  1
Affiliations
Review

Skin aging from mechanisms to interventions: focusing on dermal aging

Sun Hye Shin et al. Front Physiol. .

Abstract

Skin aging is a multifaceted process that involves intrinsic and extrinsic mechanisms that lead to various structural and physiological changes in the skin. Intrinsic aging is associated with programmed aging and cellular senescence, which are caused by endogenous oxidative stress and cellular damage. Extrinsic aging is the result of environmental factors, such as ultraviolet (UV) radiation and pollution, and leads to the production of reactive oxygen species, ultimately causing DNA damage and cellular dysfunction. In aged skin, senescent cells accumulate and contribute to the degradation of the extracellular matrix, which further contributes to the aging process. To combat the symptoms of aging, various topical agents and clinical procedures such as chemical peels, injectables, and energy-based devices have been developed. These procedures address different symptoms of aging, but to devise an effective anti-aging treatment protocol, it is essential to thoroughly understand the mechanisms of skin aging. This review provides an overview of the mechanisms of skin aging and their significance in the development of anti-aging treatments.

Keywords: cellular senescence; dermal fibroblast; rejuvenation; senotherapeutics; skin aging.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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References

    1. Alkawar A. M. M., Castellanos A. J., Carpenter M. A., Hutcherson R. J., Madkhali M. . a. O., Johnson R. M., et al. (2020). Insulin-like growth factor-1 impacts p53 target gene induction in UVB-irradiated keratinocytes and human skin. Photochem Photobiol. 96, 1332–1341. 10.1111/php.13279 - DOI - PMC - PubMed
    1. Amano S. (2016). Characterization and mechanisms of photoageing-related changes in skin. Damages of basement membrane and dermal structures. Exp. Dermatol 25 (3), 14–19. 10.1111/exd.13085 - DOI - PubMed
    1. Amano S. (2009). Possible involvement of basement membrane damage in skin photoaging. J. Investig. Dermatol Symp. Proc. 14, 2–7. 10.1038/jidsymp.2009.5 - DOI - PubMed
    1. Anderson R. R., Parrish J. A. (1983). Selective photothermolysis: Precise microsurgery by selective absorption of pulsed radiation. Science 220, 524–527. 10.1126/science.6836297 - DOI - PubMed
    1. Ayatollahi A., Firooz A., Samadi A. (2020). Evaluation of safety and efficacy of booster injections of hyaluronic acid in improving the facial skin quality. J. Cosmet. Dermatol 19, 2267–2272. 10.1111/jocd.13493 - DOI - PubMed

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