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Case Reports
. 2023 Mar-Apr;33(2):144-146.
doi: 10.4103/ijn.ijn_401_21. Epub 2022 Nov 22.

Gitelman Syndrome Presenting with Cerebellar Ataxia and Tetany

Shalini Pandya  1 , Shalin Shah  2 , Sonal Dalal  3
Affiliations
Case Reports

Gitelman Syndrome Presenting with Cerebellar Ataxia and Tetany

Shalini Pandya et al. Indian J Nephrol. 2023 Mar-Apr.

Abstract

Gitelman syndrome (GS) is salt-losing tubulopathy characterized by hypokalemia, hypomagnesemia, hypocalciuria, hyperreninemia, hyperaldosteronemia, metabolic alkalosis, and rarely hypocalcemia. Here, we describe the case of a 54-year-old man who presented with cerebellar signs and tetany. On investigation, he was found to have hypokalemia, hypocalcemia, hypomagnesemia, metabolic alkalosis, and high urinary chloride levels. On correction of metabolic parameters, he became asymptomatic. In cases of unexplained recurrent hypokalemia, hypocalcemia and hypomagnesemia, the diagnosis of GS should be considered.

Keywords: Cerebellar Ataxia; Gitelman syndrome; hypocalcemia; tetany.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
MRI (brain) flair image (a) showing the subacute infarct in cerebellar vermis (marked by the pointer). (b) Repeat scan after 3 months is normal. MRI = magnetic resonance imaging
See this image and copyright information in PMC

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References

    1. Gitelman HJ, Graham JB, Welt LG. A new familial disorder characterized by hypokalemia and hypomagnesemia. Trans Assoc Am Physicians. 1966;79:221–35. - PubMed
    1. Blanchard A, Bockenhauer D, Bolignano D, Calò LA, Cosyns E, Devuyst O, et al. Gitelman syndrome:Consensus and guidance from a Kidney disease:Improving global outcomes (KDIGO) controversies conference. Kidney Int. 2017;91:24–33. - PubMed
    1. Urwin S, Willows J, Sayer JA. The challenges of diagnosis and management of Gitelman syndrome. Clin Endocrinol (Oxf) 2020;92:3–10. - PubMed
    1. Cotovio P, Silva C, Oliveira N, Costa F. Gitelman syndrome. BMJ Case Rep. 2013;2013:bcr2013009095. - PMC - PubMed
    1. Ahmed S, Qayyum M, Farooq F. Quadriparesis in an adult--Gitelman syndrome. J Pak Med Assoc. 2011;61:182–4. - PubMed

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