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Review
. 2023 May 11;10(5):342.
doi: 10.3390/vetsci10050342.

Review of Canine Lymphoma Treated with Chemotherapy-Outcomes and Prognostic Factors

Peter Bennett  1   2 , Peter Williamson  1 , Rosanne Taylor  1
Affiliations
Review

Review of Canine Lymphoma Treated with Chemotherapy-Outcomes and Prognostic Factors

Peter Bennett et al. Vet Sci. .

Abstract

While canine lymphoma is a relatively common and important disease seen by veterinarians, there are limited comprehensive reviews of the literature regarding the remission and survival times following chemotherapy, and the associated prognostic factors. This comprehensive thematic review covers the available veterinary literature covering treatment outcomes and identified prognostic factors. A lack of standardised approaches to evaluate and report the outcomes was identified, including factors that would alter the duration of responses by weeks, or occasionally months. After publication of the suggested reporting criteria, this has improved but is still not uniformly applied. The prognostic factors included for evaluation varied from as few as three to seventeen, with over 50 studies using only univariate analysis. Individual papers reported much longer outcomes than others, but assessing the outcomes overall, there has been minimal change over the last 40 years. This supports the belief that novel approaches for lymphoma therapy will be required to substantively improve outcomes.

Keywords: cancer; chemotherapy; dog; lymphoma; prognostic factors; remission; survival.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Median remission duration for dogs with generalised lymphoma treated with chemotherapy plotted against date of paper publication.
Figure 2
Figure 2
Median survival duration for dogs with generalised lymphoma treated with chemotherapy plotted against date of paper publication.
Figure 3
Figure 3
Median remission duration of dogs with generalised B-cell lymphoma treated with chemotherapy plotted against date of paper publication.
Figure 4
Figure 4
Median survival duration of dogs with generalised B-cell lymphoma treated with chemotherapy plotted against date of paper publication.
See this image and copyright information in PMC

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