Inflammatory cytokines and depression symptoms following hematopoietic cell transplantation

Ashley M Nelson¹, Alexandra A Erdmann², Christopher L Coe³, Mark B Juckett⁴, Keayra Morris⁵, Jennifer M Knight⁵, Peiman Hematti⁶, Erin S Costanzo⁷

Affiliations

¹ Department of Psychiatry, Harvard Medical School/Massachusetts General Hospital, Boston, MA, USA.
² Department of Pediatrics, Division of Pediatric Cardiology, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, USA.
³ Department of Psychology, University of Wisconsin-Madison, Madison, WI, USA.
⁴ Division of Hematology, Oncology and Transplantation, University of Minnesota, Minneapolis, MN, USA.
⁵ Department of Psychiatry and Behavioral Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.
⁶ Department of Medicine, Division of Hematology and Oncology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA; Carbone Cancer Center, University of Wisconsin-Madison, Madison, WI, USA.
⁷ Carbone Cancer Center, University of Wisconsin-Madison, Madison, WI, USA; Department of Medicine, Division of Hematology and Oncology, School of Medicine and Public Health, University of Wisconsin- Madison, Madison, WI, USA. Electronic address: ecostanzo@wisc.edu.

PMID: 37236325
PMCID: PMC10524437
DOI: 10.1016/j.bbi.2023.05.012

Inflammatory cytokines and depression symptoms following hematopoietic cell transplantation

Ashley M Nelson et al. Brain Behav Immun. 2023 Aug.

. 2023 Aug:112:11-17.

doi: 10.1016/j.bbi.2023.05.012. Epub 2023 May 25.

Authors

Ashley M Nelson¹, Alexandra A Erdmann², Christopher L Coe³, Mark B Juckett⁴, Keayra Morris⁵, Jennifer M Knight⁵, Peiman Hematti⁶, Erin S Costanzo⁷

Affiliations

¹ Department of Psychiatry, Harvard Medical School/Massachusetts General Hospital, Boston, MA, USA.
² Department of Pediatrics, Division of Pediatric Cardiology, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, USA.
³ Department of Psychology, University of Wisconsin-Madison, Madison, WI, USA.
⁴ Division of Hematology, Oncology and Transplantation, University of Minnesota, Minneapolis, MN, USA.
⁵ Department of Psychiatry and Behavioral Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.
⁶ Department of Medicine, Division of Hematology and Oncology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA; Carbone Cancer Center, University of Wisconsin-Madison, Madison, WI, USA.
⁷ Carbone Cancer Center, University of Wisconsin-Madison, Madison, WI, USA; Department of Medicine, Division of Hematology and Oncology, School of Medicine and Public Health, University of Wisconsin- Madison, Madison, WI, USA. Electronic address: ecostanzo@wisc.edu.

PMID: 37236325
PMCID: PMC10524437
DOI: 10.1016/j.bbi.2023.05.012

Abstract

Increased synthesis and release of inflammatory signalling proteins is common among individuals with hematologic malignancies undergoing hematopoietic cell transplantation (HCT) due to intensive conditioning regimens and complications such as graft-versus-host-disease and infections. Prior research indicates that inflammatory responses can activate central nervous system pathways that evoke changes in mood. This study examined relationships between markers of inflammatory activity and depression symptoms following HCT. Individuals undergoing allogeneic (n = 84) and autologous (n = 155) HCT completed measures of depression symptoms pre-HCT and 1, 3, and 6 months post-HCT. Proinflammatory (IL-6, TNF-α) and regulatory (IL-10) cytokines were assessed by ELISA in peripheral blood plasma. Mixed-effects linear regression models indicated that patients with elevated IL-6 and IL-10 reported more severe depression symptoms at the post-HCT assessments. These findings were replicated when examining both allogeneic and autologous samples. Follow-up analyses clarified that relationships were strongest for neurovegetative, rather than cognitive or affective, symptoms of depression. These findings suggest that anti-inflammatory therapeutics targeting an inflammatory mediator of depression could improve quality of life of HCT recipients.

Keywords: Cytokines; Depression; Hematopoietic stem cell transplantation; Inflammation.

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Conflict of interest statement

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

References

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Inflammatory cytokines and depression symptoms following hematopoietic cell transplantation

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Inflammatory cytokines and depression symptoms following hematopoietic cell transplantation

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