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Review
. 2023 Aug:93:123-128.
doi: 10.1016/j.semcancer.2023.05.008. Epub 2023 May 24.

Advancements in small cell lung cancer

Jung-Hoon Lee  1 , Ashish Saxena  2 , Giuseppe Giaccone  2
Affiliations
Review

Advancements in small cell lung cancer

Jung-Hoon Lee et al. Semin Cancer Biol. 2023 Aug.

Abstract

Small cell lung cancer (SCLC) is a recalcitrant cancer with an urgent need for novel therapeutics, preclinical models, and elucidation of the molecular pathways responsible for its rapid resistance. Recently, there have been many significant advancements in our knowledge of SCLC that led to the development of novel treatments. This review will go over the recent attempts to provide new molecular subcategorization of SCLC, recent breakthroughs in various systemic treatments including immunotherapy, targeted therapy, cellular therapy, as well as advancements in radiation therapy.

Keywords: Cell cycle regulator inhibitors; Immunotherapy; Lung cancer; Small cell lung cancer; Targeted therapy.

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Conflict of interest statement

Declaration of Competing Interest A conflicting interest exists when professional judgement concerning a primary interest (such as patient’s welfare or the validity of research) may be influenced by a secondary interest (such as financial gain or personal rivalry). It may arise for the authors when they have financial interest that may influence their interpretation of their results or those of others. Examples of potential conflicts of interest include employment, consultancies, stock ownership, honoraria, paid expert testimony, patent applications/registrations, and grants or other funding.

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