Multicomponent Reactions Using C,N-Binucleophilic Nature of Aminopyrazoles: Construction of Pyrazole-Fused Heterocycles

Abstract

Synthesis of pyrazole-fused heterocycles has gained considerable attention in recent years due to their wide applications in medicinal chemistry. Aminopyrazoles are versatile building blocks for the synthesis of pyrazole-fused heterocycles by multicomponent reactions. Due to the presence of multiple reaction sites, they have fascinating chemical reactivity. Thus, they have been extensively used in multicomponent reactions for the construction of pyrazole-fused heterocycles. Although few review articles on the preparation and applications of aminopyrazoles are known in the literature, to date there is no dedicated review article on the construction of pyrazole-fused heterocycles exploring the reactivity of amino pyrazoles as C,N-binucleophiles in multicomponent reactions. Considering this, herein the multicomponent reactions for the construction of pyrazole-fused heterocycles exploring C,N-binucleophilic nature of amino pyrazoles have been reported.

Keywords: Aminopyrazoles; C,N-Binucleophiles; Multicomponent reactions; Pyrazole-fused heterocycles.