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Review
. 2023 May 15;10(5):593.
doi: 10.3390/bioengineering10050593.

The Current Role and Future Applications of Machine Perfusion in Liver Transplantation

Sebastian M Staubli  1 , Carlo D L Ceresa  1   2 , Joerg M Pollok  1   3
Affiliations
Review

The Current Role and Future Applications of Machine Perfusion in Liver Transplantation

Sebastian M Staubli et al. Bioengineering (Basel). .

Abstract

The relative paucity of donor livers suitable for transplantation has sparked innovations to preserve and recondition organs to expand the pool of transplantable organs. Currently, machine perfusion techniques have led to the improvement of the quality of marginal livers and to prolonged cold ischemia time and have allowed for the prediction of graft function through the analysis of the organ during perfusion, improving the rate of organ use. In the future, the implementation of organ modulation might expand the scope of machine perfusion beyond its current usage. The aim of this review was to provide an overview of the current clinical use of machine perfusion devices in liver transplantation and to provide a perspective for future clinical use, including therapeutic interventions in perfused donor liver grafts.

Keywords: hypothermic machine perfusion; normothermic machine perfusion; normothermic regional perfusion; orthotopic liver transplantation.

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Conflict of interest statement

The authors declare no conflict of interest.

References

    1. Carrel A., Lindbergh C.A. The Culture of Whole Organs. Science. 1935;81:621–623. doi: 10.1126/science.81.2112.621. - DOI - PubMed
    1. Starzl T.E., Groth C.G., Brettschneider L., Penn I., Fulginiti V.A., Moon J.B., Blanchard H., Martin A.J., Jr., Porter K.A. Orthotopic Homotransplantation of the Human Liver. Ann. Surg. 1968;168:392–415. doi: 10.1097/00000658-196809000-00009. - DOI - PMC - PubMed
    1. Wahlberg J.A., Southard J.H., Belzer F.O. Development of a Cold Storage Solution for Pancreas Preservation. Cryobiology. 1986;23:477–482. doi: 10.1016/0011-2240(86)90056-8. - DOI - PubMed
    1. Belzer F.O., Ashby B.S., Dunphy J.E. 24-hour and 72-hour preservation of canine kidneys. Lancet. 1967;290:536–539. doi: 10.1016/S0140-6736(67)90498-9. - DOI - PubMed
    1. Saidi R.F., Kenari S.K.H. Liver Ischemia/Reperfusion Injury: An Overview. J. Investig. Surg. 2014;27:366–379. doi: 10.3109/08941939.2014.932473. - DOI - PubMed

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