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. 2023 May 9;13(10):1670.
doi: 10.3390/diagnostics13101670.

Breath Volatile Organic Compounds in Surveillance of Gastric Cancer Patients following Radical Surgical Management

Roberts Škapars  1   2 , Evita Gašenko  1   2 , Yoav Y Broza  3 , Armands Sīviņš  1   2 , Inese Poļaka  1 , Inga Bogdanova  1   2 , Andrejs Pčolkins  1   2 , Viktors Veliks  1 , Valdis Folkmanis  1 , Anna Lesčinska  1   2 , Inta Liepniece-Karele  1   2 , Hossam Haick  3 , Ingrīda Rumba-Rozenfelde  1 , Mārcis Leja  1   2
Affiliations

Breath Volatile Organic Compounds in Surveillance of Gastric Cancer Patients following Radical Surgical Management

Roberts Škapars et al. Diagnostics (Basel). .

Abstract

As of today, there is a lack of a perfect non-invasive test for the surveillance of patients for potential relapse following curative treatment. Breath volatile organic compounds (VOCs) have been demonstrated to be an accurate diagnostic tool for gastric cancer (GC) detection; here, we aimed to prove the yield of the markers in surveillance, i.e., following curative surgical management. Patients were sampled in regular intervals before and within 3 years following curative surgery for GC; gas chromatography-mass spectrometry (GC-MS) and nanosensor technologies were used for the VOC assessment. GC-MS measurements revealed a single VOC (14b-Pregnane) that significantly decreased at 12 months, and three VOCs (Isochiapin B, Dotriacontane, Threitol, 2-O-octyl-) that decreased at 18 months following surgery. The nanomaterial-based sensors S9 and S14 revealed changes in the breath VOC content 9 months after surgery. Our study results confirm the cancer origin of the particular VOCs, as well as suggest the value of breath VOC testing for cancer patient surveillance, either during the treatment phase or thereafter, for potential relapse.

Keywords: cancer follow-up; gas chromatography-mass spectrometry; gastric cancer; nanosensors; volatile organic compounds.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Flow chart for a patient exclusion process.
Figure 2
Figure 2
Description of sampling intervals. T—time, mo—a month after the operation. Blue arrows showing breath test time.
Figure 3
Figure 3
Showing different breath prints nine months after the curative operation. Mo—months.
See this image and copyright information in PMC

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