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Review
. 2023 May 7;10(5):844.
doi: 10.3390/children10050844.

The Diagnosis of "Pervasive Developmental Disorder Not Otherwise Specified": A Systematic Literature Review

Affiliations
Review

The Diagnosis of "Pervasive Developmental Disorder Not Otherwise Specified": A Systematic Literature Review

Agostino Carbone et al. Children (Basel). .

Abstract

(1) Background: The study deepens the diagnosis of "pervasive developmental disorder not otherwise specified" (PDD-NOS), a subthreshold diagnosis introduced in DSM-IV and then absorbed into the broader spectrum disorder of autism in DSM 5. The presence of people still attributed with a diagnosis of PDD-NOS can cause confusion in the understanding of this disorder, which is no longer present in the current diagnostic system. This review aims to gain a deeper understanding of the characteristics and boundaries of diagnosis, its use within the scientific community, and the long-term stability of that diagnosis. (2) Methods: The Prisma method was used to carry out the literature review; the scientific papers were selected using scientific search engines, including SCOPUS, PUBMED, and PsychINFO. Twenty-three articles were finally selected, and a meticulous reading was carried out in relation to the research questions. (3) Results: Four cross-cutting categories were identified: (1) diagnosis; (2) differential diagnosis; (3) prognosis; and (4) comorbidity. (4) Conclusions: Limits have emerged regarding the consistency, sensitivity, and the stability of PDD-NOS. The inclusion of this diagnosis within the broader autism spectrum disorder category coined in DSM-5 appears applicable.

Keywords: DSM; PDD-NOS; autism spectrum disorder; clinical psychology; diagnostic process; neuropsychiatry of childhood.

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Conflict of interest statement

The authors declare that they have no conflicts of interest.

Figures

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Figure 1
Flow-chart.

References

    1. American Psychiatric Association . Diagnostic and Statistical Manual of Mental Disorders. 4th ed. American Psychiatric Association; Washington, DC, USA: 1994. - DOI
    1. American Psychiatric Association . Diagnostic and Statistical Manual of Mental Disorders. 5th ed. American Psychiatric Association; Washington, DC, USA: 2013. - DOI
    1. De Bruin E.I., Ferdinand R.F., Meester S., de Nijs P.F., Verheij F. High rates of psychiatric co-morbidity in PDD-NOS. J. Autism Dev. Disord. 2007;37:877–886. doi: 10.1007/s10803-006-0215-x. - DOI - PubMed
    1. World Health Organization . International Statistical Classification of Diseases and Related Health Problems. 10th ed. World Health Organization; Geneva, Switzerland: 2016. [(accessed on 1 February 2023)]. Available online: https://icd.who.int/
    1. Brennan L., Barton M., Chen C., James J., Fein D. Detecting Subgroups in Children Diagnosed with Pervasive Developmental Disorder—Not Otherwise Specified. J. Autism Dev. Disord. 2015;45:1329–1344. doi: 10.1007/s10803-014-2295-3. - DOI - PMC - PubMed

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