Neonatal Drug Formularies-A Global Scope

Dotan Shaniv^{1

2}, Srinivas Bolisetty³, Thomas E Young^{4

5

6}, Barry Mangum^{4

7

8}, Sean Ainsworth⁹, Linda Elbers¹⁰, Petra Schultz¹⁰, Melanie Cucchi¹¹, Saskia N de Wildt^{12

13

14}, Tjitske M van der Zanden^{12

14

15}, Neil Caldwell¹⁶, Anne Smits^{17

18}, Karel Allegaert^{17

19

20}

Affiliations

¹ Pharmacy Services, Kaplan Medical Center (Clalit Health Services), Pasternak St., P.O. Box 1, Rehovot 76100, Israel.
² Neonatal Intensive Care Unit, Kaplan Medical Center (Clalit Health Services), Pasternak St., P.O. Box 1, Rehovot 76100, Israel.
³ Division of Newborn Services, Royal Hospital for Women, Sydney 2031, Australia.
⁴ Co-Founder of Neofax and Acorn Publishing, Raleigh, NC 27610, USA.
⁵ WakeMed Health and Hospitals, Raleigh, NC 27610, USA.
⁶ School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA.
⁷ Co-Founder and CEO of Paidion Research Inc., Durham, NC 27707, USA.
⁸ School of Medicine, Duke University, Durham, NC 27710, USA.
⁹ Directorate of Women and Children's Health, Victoria Hospital, Kirkcaldy, Scotland KY2 5AH, UK.
¹⁰ Micromedex/NeoFax Editorial Services, Merative, 100 Phoenix Drive, Ann Arbor, MI 48108, USA.
¹¹ Wolters Kluwer-Health, Clinical Effectiveness, Waltham, MA 02453, USA.
¹² Department of Pharmacology and Toxicology, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.
¹³ Intensive Care and Department of Pediatric Surgery, Erasmus MC-Sophia Children's Hospital, 3015 CN Rotterdam, The Netherlands.
¹⁴ Dutch Knowledge Center Pharmacotherapy for Children, Postal Box 25270, 3001 HG Rotterdam, The Netherlands.
¹⁵ Department of Pediatrics, Erasmus MC Sophia Children's Hospital, 3015 CN Rotterdam, The Netherlands.
¹⁶ Pharmacy Department, Wirral University Teaching Hospital/Liverpool John Moores University, Arrowe Park Road, Upton, Merseyside CH49 5PE, UK.
¹⁷ Department of Development and Regeneration, KU Leuven, 3000 Leuven, Belgium.
¹⁸ Neonatal Intensive Care Unit, University Hospitals Leuven, 3000 Leuven, Belgium.
¹⁹ Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, 3000 Leuven, Belgium.
²⁰ Department of Hospital Pharmacy, Erasmus MC, 3015 GD Rotterdam, The Netherlands.

PMID: 37238396
PMCID: PMC10217712
DOI: 10.3390/children10050848

Neonatal Drug Formularies-A Global Scope

Dotan Shaniv et al. Children (Basel). 2023.

. 2023 May 8;10(5):848.

doi: 10.3390/children10050848.

Authors

Affiliations

¹ Pharmacy Services, Kaplan Medical Center (Clalit Health Services), Pasternak St., P.O. Box 1, Rehovot 76100, Israel.
² Neonatal Intensive Care Unit, Kaplan Medical Center (Clalit Health Services), Pasternak St., P.O. Box 1, Rehovot 76100, Israel.
³ Division of Newborn Services, Royal Hospital for Women, Sydney 2031, Australia.
⁴ Co-Founder of Neofax and Acorn Publishing, Raleigh, NC 27610, USA.
⁵ WakeMed Health and Hospitals, Raleigh, NC 27610, USA.
⁶ School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA.
⁷ Co-Founder and CEO of Paidion Research Inc., Durham, NC 27707, USA.
⁸ School of Medicine, Duke University, Durham, NC 27710, USA.
⁹ Directorate of Women and Children's Health, Victoria Hospital, Kirkcaldy, Scotland KY2 5AH, UK.
¹⁰ Micromedex/NeoFax Editorial Services, Merative, 100 Phoenix Drive, Ann Arbor, MI 48108, USA.
¹¹ Wolters Kluwer-Health, Clinical Effectiveness, Waltham, MA 02453, USA.
¹² Department of Pharmacology and Toxicology, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.
¹³ Intensive Care and Department of Pediatric Surgery, Erasmus MC-Sophia Children's Hospital, 3015 CN Rotterdam, The Netherlands.
¹⁴ Dutch Knowledge Center Pharmacotherapy for Children, Postal Box 25270, 3001 HG Rotterdam, The Netherlands.
¹⁵ Department of Pediatrics, Erasmus MC Sophia Children's Hospital, 3015 CN Rotterdam, The Netherlands.
¹⁶ Pharmacy Department, Wirral University Teaching Hospital/Liverpool John Moores University, Arrowe Park Road, Upton, Merseyside CH49 5PE, UK.
¹⁷ Department of Development and Regeneration, KU Leuven, 3000 Leuven, Belgium.
¹⁸ Neonatal Intensive Care Unit, University Hospitals Leuven, 3000 Leuven, Belgium.
¹⁹ Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, 3000 Leuven, Belgium.
²⁰ Department of Hospital Pharmacy, Erasmus MC, 3015 GD Rotterdam, The Netherlands.

PMID: 37238396
PMCID: PMC10217712
DOI: 10.3390/children10050848

Abstract

Neonatal drug information (DI) is essential for safe and effective pharmacotherapy in (pre)term neonates. Such information is usually absent from drug labels, making formularies a crucial part of the neonatal clinician's toolbox. Several formularies exist worldwide, but they have never been fully mapped or compared for content, structure and workflow. The objective of this review was to identify neonatal formularies, explore (dis)similarities, and raise awareness of their existence. Neonatal formularies were identified through self-acquaintance, experts and structured search. A questionnaire was sent to all identified formularies to provide details on formulary function. An original extraction tool was employed to collect DI from the formularies on the 10 most commonly used drugs in pre(term) neonates. Eight different neonatal formularies were identified worldwide (Europe, USA, Australia-New Zealand, Middle East). Six responded to the questionnaire and were compared for structure and content. Each formulary has its own workflow, monograph template and style, and update routine. Focus on certain aspects of DI also varies, as well as the type of initiative and funding. Clinicians should be aware of the various formularies available and their differences in characteristics and content to use them properly for the benefit of their patients.

Keywords: drug database; drug formulary; drug information; neonatal; pediatric.

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Conflict of interest statement

K.A. and T.E.Y. serve as international collaborators at the Australasian Neonatal Medicines Formulary. K.A. and A.S. are members of the multidisciplinary editorial board of the Dutch Pediatric Formulary and its special expert group for neonatology. M.C. serves as Associate Director—Pediatric/Neonatal, Clinical Effectiveness, Lexicomp/UpToDate/Facts and Comparisons/Medi-Span/Emmi. N.C. serves as Deputy Chair of the Paediatric Formulary Committee of the BNF for Children. L.E. serves as Clinical Content Strategy leader for Merative Micromedex. P.S. serves as Editor in Chief for Merative Micromedex. S.A. has, since 2014, received Royalties from the sales of Neonatal Formulary. T.Z. is the Managing Director of the Dutch Pediatric Formulary. S.N.W. is the Medical Director of the Dutch Pediatric Formulary. S.B. is the Chair of the Australasian Neonatal Medicines Formulary (ANMF) group. D.S. declares no conflict of interest.

Figures

**Figure 1**
Geographic pinpointing of contacted formularies/colleagues. Purple boxes indicate contacted formularies that responded; boxes in green indicate contacted formularies that did not respond; boxes in red indicate contacted colleagues where no formularies were found. ANMF = Australasian Neonatal Medicines Formulary, BNF for Children = British National Formulary for Children, DPF = Dutch Pediatric Formulary, NNF = Neonatal Formulary. (Image source: www.freeworldmaps.net, used with permission in agreement with source’s terms and conditions of use).

See this image and copyright information in PMC

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Neonatal Drug Formularies-A Global Scope

Affiliations

Neonatal Drug Formularies-A Global Scope

Authors

Affiliations

Abstract

Conflict of interest statement

Figures

References