Incidental Hyperferritinemia in Very Young Infants with Mild Symptoms of COVID-19 Disease

doi:10.3390/children10050874

Case Reports

. 2023 May 12;10(5):874.

doi: 10.3390/children10050874.

Incidental Hyperferritinemia in Very Young Infants with Mild Symptoms of COVID-19 Disease

Yuka Shishido¹, Haruhiko Nakamura^{1

2}, Tomohiro Nakagawa³, Shinsuke Kanou¹, Takeshi Ito¹, Shota Kuwana¹, Chiharu Ota^{3

4}

Affiliations

¹ Department of Pediatrics, Japanese Red Cross Ishinomaki Hospital, Ishinomaki 9868522, Japan.
² Department of Neurology, Miyagi Children's Hospital, Sendai 9893126, Japan.
³ Department of Pediatrics, Tohoku University Hospital, Sendai 9808574, Japan.
⁴ Department of Development and Environmental Medicine, Tohoku University Graduate School of Medicine, Sendai 9808575, Japan.

PMID: 37238422
PMCID: PMC10217696
DOI: 10.3390/children10050874

Case Reports

Incidental Hyperferritinemia in Very Young Infants with Mild Symptoms of COVID-19 Disease

Yuka Shishido et al. Children (Basel). 2023.

. 2023 May 12;10(5):874.

doi: 10.3390/children10050874.

Authors

Yuka Shishido¹, Haruhiko Nakamura^{1

2}, Tomohiro Nakagawa³, Shinsuke Kanou¹, Takeshi Ito¹, Shota Kuwana¹, Chiharu Ota^{3

4}

Affiliations

¹ Department of Pediatrics, Japanese Red Cross Ishinomaki Hospital, Ishinomaki 9868522, Japan.
² Department of Neurology, Miyagi Children's Hospital, Sendai 9893126, Japan.
³ Department of Pediatrics, Tohoku University Hospital, Sendai 9808574, Japan.
⁴ Department of Development and Environmental Medicine, Tohoku University Graduate School of Medicine, Sendai 9808575, Japan.

PMID: 37238422
PMCID: PMC10217696
DOI: 10.3390/children10050874

Abstract

Background: The number of children infected with novel coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has increased during the outbreak of the Omicron strain. Hyperferritinemia has been reported in severe cases of COVID-19, and in children or neonates with multisystem inflammatory syndrome (MIS). Hyperferritinemia is considered to be one of the signs of MIS, but thus far, there have been few summarized reports on it. We retrospectively analyzed four infants less than 3 months of age with SARS-CoV-2 infections treated in our institution during the outbreak of the Omicron strain.

Results: most patients were in good condition, but hyperferritinemia was observed in all of four cases.

Conclusions: Hyperferritinemia can be observed in infantile COVID-19 patients even with mild symptoms. It is necessary to carefully monitor their clinical course and monitor the patients.

Keywords: Japan; early infantile COVID-19; hyperferritinemia; multisystem inflammatory syndrome.

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Conflict of interest statement

The authors declare no conflicts of interest.

References

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1. Sobolewska-Pilarczyk M., Pokorska-Śpiewak M., Stachowiak A., Marczyńska M., Talarek E., Ołdakowska A., Kucharek I., Sybilski A., Mania A., Figlerowicz M., et al. COVID-19 infections in infants. Sci. Rep. 2022;12:7765. doi: 10.1038/s41598-022-11068-0. - DOI - PMC - PubMed
1. Henderson L.A., Canna S.W., Friedman K.G., Gorelik M., Lapidus S.K., Bassiri H., Behrens E.M., Ferris A., Kernan K.F., Schulert G.S., et al. American College of Rheumatology Clinical Guidance for Multisystem Inflammatory Syndrome in Children Associated with SARS-CoV-2 and Hyperinflammation in Pediatric COVID-19: Version 2. Arthritis Rheumatol. 2021;73:e13–e29. doi: 10.1002/art.41616. - DOI - PMC - PubMed
1. Cattalini M., Della Paolera S., Zunica F., Bracaglia C., Giangreco M., Verdoni L., Meini S., Sottile R., Caorsi R., Zuccotti G., et al. Defining Kawasaki disease and pediatric inflammatory multisystem syndrome-temporally associated to SARS-CoV-2 infection during SARS-CoV-2 epidemic in Italy: Results from a national, multicenter survey. Pediatr. Rheumatol. 2021;19:29. doi: 10.1186/s12969-021-00511-7. - DOI - PMC - PubMed

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[1] Li Q., Guan X., Wu P., Wang X., Zhou L., Tong Y., Ren R., Leung K.S.M., Lau E.H.Y., Wong J.Y., et al. Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus–Infected Pneumonia. [(accessed on 23 February 2022)];N. Engl. J. Med. 2020 382:1199–1207. doi: 10.1056/NEJMoa2001316. Available online: https://www.nejm.org/doi/full/10.1056/nejmoa2001316. - DOI - DOI - PMC - PubMed

[2] Li Q., Guan X., Wu P., Wang X., Zhou L., Tong Y., Ren R., Leung K.S.M., Lau E.H.Y., Wong J.Y., et al. Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus–Infected Pneumonia. [(accessed on 23 February 2022)];N. Engl. J. Med. 2020 382:1199–1207. doi: 10.1056/NEJMoa2001316. Available online: https://www.nejm.org/doi/full/10.1056/nejmoa2001316. - DOI - DOI - PMC - PubMed

[3] Pokorska-Śpiewak M., Talarek E., Mania A., Pawłowska M., Popielska J., Zawadka K., Figlerowicz M., Mazur-Melewska K., Faltin K., Ciechanowski P., et al. Clinical and Epidemiological Characteristics of 1283 Pediatric Patients with Coronavirus Disease 2019 during the First and Second Waves of the Pandemic—Results of the Pediatric Part of a Multicenter Polish Register SARSTer. J. Clin. Med. 2021;10:5098. doi: 10.3390/jcm10215098. - DOI - PMC - PubMed

[4] Pokorska-Śpiewak M., Talarek E., Mania A., Pawłowska M., Popielska J., Zawadka K., Figlerowicz M., Mazur-Melewska K., Faltin K., Ciechanowski P., et al. Clinical and Epidemiological Characteristics of 1283 Pediatric Patients with Coronavirus Disease 2019 during the First and Second Waves of the Pandemic—Results of the Pediatric Part of a Multicenter Polish Register SARSTer. J. Clin. Med. 2021;10:5098. doi: 10.3390/jcm10215098. - DOI - PMC - PubMed

[5] Sobolewska-Pilarczyk M., Pokorska-Śpiewak M., Stachowiak A., Marczyńska M., Talarek E., Ołdakowska A., Kucharek I., Sybilski A., Mania A., Figlerowicz M., et al. COVID-19 infections in infants. Sci. Rep. 2022;12:7765. doi: 10.1038/s41598-022-11068-0. - DOI - PMC - PubMed

[6] Sobolewska-Pilarczyk M., Pokorska-Śpiewak M., Stachowiak A., Marczyńska M., Talarek E., Ołdakowska A., Kucharek I., Sybilski A., Mania A., Figlerowicz M., et al. COVID-19 infections in infants. Sci. Rep. 2022;12:7765. doi: 10.1038/s41598-022-11068-0. - DOI - PMC - PubMed

[7] Henderson L.A., Canna S.W., Friedman K.G., Gorelik M., Lapidus S.K., Bassiri H., Behrens E.M., Ferris A., Kernan K.F., Schulert G.S., et al. American College of Rheumatology Clinical Guidance for Multisystem Inflammatory Syndrome in Children Associated with SARS-CoV-2 and Hyperinflammation in Pediatric COVID-19: Version 2. Arthritis Rheumatol. 2021;73:e13–e29. doi: 10.1002/art.41616. - DOI - PMC - PubMed

[8] Henderson L.A., Canna S.W., Friedman K.G., Gorelik M., Lapidus S.K., Bassiri H., Behrens E.M., Ferris A., Kernan K.F., Schulert G.S., et al. American College of Rheumatology Clinical Guidance for Multisystem Inflammatory Syndrome in Children Associated with SARS-CoV-2 and Hyperinflammation in Pediatric COVID-19: Version 2. Arthritis Rheumatol. 2021;73:e13–e29. doi: 10.1002/art.41616. - DOI - PMC - PubMed

[9] Cattalini M., Della Paolera S., Zunica F., Bracaglia C., Giangreco M., Verdoni L., Meini S., Sottile R., Caorsi R., Zuccotti G., et al. Defining Kawasaki disease and pediatric inflammatory multisystem syndrome-temporally associated to SARS-CoV-2 infection during SARS-CoV-2 epidemic in Italy: Results from a national, multicenter survey. Pediatr. Rheumatol. 2021;19:29. doi: 10.1186/s12969-021-00511-7. - DOI - PMC - PubMed

[10] Cattalini M., Della Paolera S., Zunica F., Bracaglia C., Giangreco M., Verdoni L., Meini S., Sottile R., Caorsi R., Zuccotti G., et al. Defining Kawasaki disease and pediatric inflammatory multisystem syndrome-temporally associated to SARS-CoV-2 infection during SARS-CoV-2 epidemic in Italy: Results from a national, multicenter survey. Pediatr. Rheumatol. 2021;19:29. doi: 10.1186/s12969-021-00511-7. - DOI - PMC - PubMed

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Incidental Hyperferritinemia in Very Young Infants with Mild Symptoms of COVID-19 Disease

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Incidental Hyperferritinemia in Very Young Infants with Mild Symptoms of COVID-19 Disease

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