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Case Reports
. 2023 May 12;10(5):874.
doi: 10.3390/children10050874.

Incidental Hyperferritinemia in Very Young Infants with Mild Symptoms of COVID-19 Disease

Yuka Shishido  1 , Haruhiko Nakamura  1   2 , Tomohiro Nakagawa  3 , Shinsuke Kanou  1 , Takeshi Ito  1 , Shota Kuwana  1 , Chiharu Ota  3   4
Affiliations
Case Reports

Incidental Hyperferritinemia in Very Young Infants with Mild Symptoms of COVID-19 Disease

Yuka Shishido et al. Children (Basel). .

Abstract

Background: The number of children infected with novel coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has increased during the outbreak of the Omicron strain. Hyperferritinemia has been reported in severe cases of COVID-19, and in children or neonates with multisystem inflammatory syndrome (MIS). Hyperferritinemia is considered to be one of the signs of MIS, but thus far, there have been few summarized reports on it. We retrospectively analyzed four infants less than 3 months of age with SARS-CoV-2 infections treated in our institution during the outbreak of the Omicron strain.

Results: most patients were in good condition, but hyperferritinemia was observed in all of four cases.

Conclusions: Hyperferritinemia can be observed in infantile COVID-19 patients even with mild symptoms. It is necessary to carefully monitor their clinical course and monitor the patients.

Keywords: Japan; early infantile COVID-19; hyperferritinemia; multisystem inflammatory syndrome.

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Conflict of interest statement

The authors declare no conflicts of interest.

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