Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 May 11;11(5):1419.
doi: 10.3390/biomedicines11051419.

Adipokines in Pregnancy: A Systematic Review of Clinical Data

Noura Kabbani  1 , Matthias Blüher  2   3 , Holger Stepan  1 , Michael Stumvoll  2 , Thomas Ebert  2 , Anke Tönjes  2 , Susanne Schrey-Petersen  1
Affiliations
Review

Adipokines in Pregnancy: A Systematic Review of Clinical Data

Noura Kabbani et al. Biomedicines. .

Abstract

Adipokines are signaling proteins involved in metabolic, endocrinological, vascular and immunogenic processes. Associations of various adipokines with not only insulin resistance but also with increased insulin sensitivity, increased systolic blood pressure, and atherosclerosis highlight the significance of adipokines in several components of metabolic syndrome and metabolic diseases in general. As pregnancy presents a unique metabolic state, the role of adipokines in pregnancy, and even in various pregnancy complications, appears to be key to elucidating these metabolic processes. Many studies in recent years have attempted to clarify the role of adipokines in pregnancy and gestational pathologies. In this review, we aim to investigate the changes in maternal adipokine levels in physiological gestation, as well as the association of adipokines with pregnancy pathologies, such as gestational diabetes mellitus (GDM) and preeclampsia (PE). Furthermore, we will analyze the association of adipokines in both maternal serum and cord blood with parameters of intrauterine growth and various pregnancy outcomes.

Keywords: adipokines; gestational diabetes; intrauterine growth; preeclampsia; pregnancy.

PubMed Disclaimer

Conflict of interest statement

M.B. received honoraria as a consultant and speaker from Amgen, AstraZeneca, Bayer, Boehringer-Ingelheim, Lilly, Novo Nordisk, Novartis, and Sanofi. All other authors declare no conflict of interest.

References

    1. Plows J.F., Stanley J.L., Baker P.N., Reynolds C.M., Vickers M.H. The Pathophysiology of Gestational Diabetes Mellitus. Int. J. Mol. Sci. 2018;19:3342. doi: 10.3390/ijms19113342. - DOI - PMC - PubMed
    1. Scherer P.E. Lilly Lecture 2005 Adipose Tissue From Lipid Storage Compartment to Endocrine Organ. Diabetes. 2006;55:1537–1545. doi: 10.2337/db06-0263. - DOI - PubMed
    1. Maachi M., Piéroni L., Bruckert E., Jardel C., Fellahi S., Hainque B., Capeau J., Bastard J.-P. Systemic Low-Grade Inflammation Is Related to Both Circulating and Adipose Tissue TNFa, Leptin and IL-6levels in Obese Women. Int. J. Obes. 2004;28:993–997. doi: 10.1038/sj.ijo.0802718. - DOI - PubMed
    1. Landon M.B., Gabbe S.G. Gestational Diabetes Mellitus. Obstet. Gynecol. 2011;118:1379–1393. doi: 10.1097/AOG.0b013e31823974e2. - DOI - PubMed
    1. Barker D.J. The Fetal and Infant Orgins of Adult Disease. Br. Med. J. 1990;301:1111. doi: 10.1136/bmj.301.6761.1111. - DOI - PMC - PubMed