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Review
. 2023 May 22;11(5):1500.
doi: 10.3390/biomedicines11051500.

Mitochondrial Dysfunction in Cardiac Diseases and Therapeutic Strategies

Yafei Huang  1 , Bingying Zhou  1
Affiliations
Review

Mitochondrial Dysfunction in Cardiac Diseases and Therapeutic Strategies

Yafei Huang et al. Biomedicines. .

Abstract

Mitochondria are the main site of intracellular synthesis of ATP, which provides energy for various physiological activities of the cell. Cardiomyocytes have a high density of mitochondria and mitochondrial damage is present in a variety of cardiovascular diseases. In this paper, we describe mitochondrial damage in mitochondrial cardiomyopathy, congenital heart disease, coronary heart disease, myocardial ischemia-reperfusion injury, heart failure, and drug-induced cardiotoxicity, in the context of the key roles of mitochondria in cardiac development and homeostasis. Finally, we discuss the main current therapeutic strategies aimed at alleviating mitochondrial impairment-related cardiac dysfunction, including pharmacological strategies, gene therapy, mitochondrial replacement therapy, and mitochondrial transplantation. It is hoped that this will provide new ideas for the treatment of cardiovascular diseases.

Keywords: cardiomyocytes; cardiovascular diseases; mitochondria; mitochondrial dysfunction; therapeutic strategies targeting mitochondria.

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Conflict of interest statement

The authors declare no conflict of interest.

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