Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2023 May 10;11(10):1373.
doi: 10.3390/healthcare11101373.

Large Pelvic Mass in a Female Adolescent: Atypical Presentation and Successful Treatment of Extraskeletal Ewing Sarcoma

Federica Perelli  1 , Giuseppe Vizzielli  2   3 , Anna Franca Cavaliere  4 , Stefano Restaino  2 , Giovanni Scambia  5 , Gian Franco Zannoni  6   7 , Damiano Arciuolo  6 , Valerio Gallotta  5
Affiliations
Case Reports

Large Pelvic Mass in a Female Adolescent: Atypical Presentation and Successful Treatment of Extraskeletal Ewing Sarcoma

Federica Perelli et al. Healthcare (Basel). .

Abstract

Extraskeletal Ewing sarcoma is a rare soft tissue tumor primarily affecting pediatric patients. The treatment is currently based on a multidisciplinary approach which allows, in cases of localized disease, good survival rates. We report the case of a 15-year-old female patient with a rapidly growing suspected pelvic mass misdiagnosed following the preliminary radiological exams, which assessed the findings as a mass of ovarian origin. The girl underwent surgery and, thanks to histopathological, immunohistochemical and real-time polymerase chain reaction (RT-PCR) examinations, it was possible to make the right diagnosis and to administer the best treatment in terms of surgery, chemotherapy and radiotherapy, obtaining a long disease-free interval and no recurrence to date.

Keywords: Ewing sarcoma; female healthcare; fertility sparing; gynecologic surgery; gynecology; pediatric gynecology.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Longitudinal section, MRI.
Figure 2
Figure 2
Solid pelvic mass, vascularized at the color Doppler, longitudinal diameter 17.95 cm, coronal diameter 14.06 cm, US.
Figure 3
Figure 3
Pelvic mass, intraoperative view.
Figure 4
Figure 4
H&E stain, low enlargement (10×).
Figure 5
Figure 5
FLI1 immunohistochemistry.
See this image and copyright information in PMC

References

    1. Kliegman R.M., Behrman R.E., Jenson H.B., Stanton B. Nelson Textbook of Pediatrics. 18th ed. Elsevier; Amsterdam, The Netherlands: 2007.
    1. de Alava E., Kawai A., Healey J.H., Fligman I., Meyers P.A., Huvos A.G., Gerald W.L., Jhanwar S.C., Argani P., Antonescu C.R., et al. EWS-FLI1 fusion transcript structure is an independent determinant of prognosis in Ewing’s sarcoma. J. Clin. Oncol. 1998;16:1248–1255. doi: 10.1200/JCO.1998.16.4.1248. - DOI - PubMed
    1. Delattre O., Zucman J., Plougastel B., Desmaze C., Melot T., Peter M., Kovar H., Joubert I., De Jong P., Rouleau G., et al. Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours. Nature. 1992;359:162–165. doi: 10.1038/359162a0. - DOI - PubMed
    1. Lu D.Y., Ellegast J.M., Ross K.N., Malone C.F., Lin S., Mabe N.W., Dharia N.V., Meyer A., Conway A., Su A.H., et al. The ETS transcription factor ETV6 constrains the transcriptional activity of EWS-FLI to promote Ewing sarcoma. Nat. Cell Biol. 2023;25:285–297. doi: 10.1038/s41556-022-01059-8. - DOI - PMC - PubMed
    1. Hense H.W., Ahrens S., Paulussen M., Lehnert M., Jürgens H. Factors associated with tumor volume and primary metastases in Ewing tumors: Results from the (EI)CESS studies. Ann. Oncol. 1999;10:1073–1078. doi: 10.1023/A:1008357018737. - DOI - PubMed

Publication types

LinkOut - more resources