Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 May 12;12(10):3429.
doi: 10.3390/jcm12103429.

One-Year and Five-Year Outcomes of Transcatheter Aortic Valve Replacement or Surgical Aortic Valve Replacement in a Taiwanese Elderly Population

Po-Han Lin  1   2 , Hao-Ji Wei  1   3 , Shih-Rong Hsieh  4 , Hung-Wen Tsai  1 , Chu-Leng Yu  1 , Wen-Lieng Lee  3   5 , Yung-Szu Wu  1
Affiliations

One-Year and Five-Year Outcomes of Transcatheter Aortic Valve Replacement or Surgical Aortic Valve Replacement in a Taiwanese Elderly Population

Po-Han Lin et al. J Clin Med. .

Abstract

Background: The aim of our study was to provide real-world data on outcomes for elderly Taiwanese patients who underwent transcatheter aortic valve replacement or surgical aortic valve replacement in different risk groups.

Methods: From March 2011 through December 2021, 177 patients with severe aortic stenosis who were ≥70 years old and had undergone TAVI (transcatheter aortic valve implantation) or SAVR (surgical aortic valve replacement) in a single center were divided by STS score (<4%, 4-8% and >8%) into three different groups. Then, we compared their clinical characteristics, operative complications, and all-cause mortality.

Results: In all risk groups, there were no significant differences in in-hospital mortality, or 1-year and 5-year mortality between patients in the TAVI and SAVR groups. In all risk groups, patients in the TAVI group had shorter hospital stay and higher rate of paravalvular leakage than the SAVR group. After univariate analysis, BMI (body mass index) < 20 was a risk factor for higher 1-year and 5-year mortality. In the multivariate analysis, acute kidney injury was an independent factor for predicting worse outcomes in terms of 1-year and 5-year mortality.

Conclusions: Taiwan elderly patients in all risk groups did not have significant differences in mortality rates between the TAVI and the SAVR group. However, the TAVI group had shorter hospital stay and higher rate of paravalvular leakage in all risk groups.

Keywords: acute kidney injury; body mass index; mortality; surgical aortic valve replacement; transcatheter aortic valve replacement.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
The flowchart of patient selection.
Figure 2
Figure 2
Five-year mortality curves of TAVI and SAVR patients in low-risk group.
Figure 3
Figure 3
Five-year mortality curves of TAVI and SAVR patients in intermediate-risk group.
Figure 4
Figure 4
Five-year mortality curves of TAVI and SAVR patients in high-risk group.
See this image and copyright information in PMC

References

    1. Voigtländer L., Twerenbold R., Schäfer U., Conradi L., Balaban Ü., Bekeredjian R., Ensminger S., Walther T., Beckmann A., Frerker C., et al. Prognostic Impact of Underweight (Body Mass Index < 20 kg/m2) in Patients With Severe Aortic Valve Stenosis Undergoing Transcatheter Aortic Valve Implantation or Surgical Aortic Valve Replacement (from the German Aortic Valve Registry [GARY]) Am. J. Cardiol. 2020;129:79–86. doi: 10.1016/j.amjcard.2020.05.002. - DOI - PubMed
    1. Winter J.E., MacInnis R.J., Wattanapenpaiboon N., Nowson C.A. BMI and all-cause mortality in older adults: A meta-analysis. Am. J. Clin. Nutr. 2014;99:875–890. doi: 10.3945/ajcn.113.068122. - DOI - PubMed
    1. Takeji Y., Taniguchi T., Morimoto T., Saito N., Ando K., Shirai S., Sakaguchi G., Arai Y., Fuku Y., Kawase Y., et al. Transcatheter Aortic Valve Implantation vs. Surgical Aortic Valve Replacement for Severe Aortic Stenosis in Real-World Clinical Practice. Circ. J. 2020;84:806–814. doi: 10.1253/circj.CJ-19-0951. - DOI - PubMed
    1. Makkar R.R., Thourani V.H., Mack M.J., Kodali S.K., Kapadia S., Webb J.G., Yoon S.-H., Trento A., Svensson L.G., Herrmann H.C., et al. Five-Year Outcomes of Transcatheter or Surgical Aortic-Valve Replacement. N. Engl. J. Med. 2020;382:799–809. doi: 10.1056/NEJMoa1910555. - DOI - PubMed
    1. Mack M.J., Leon M.B., Thourani V.H., Makkar R., Kodali S.K., Russo M., Kapadia S.R., Malaisrie S.C., Cohen D.J., Pibarot P., et al. Transcatheter Aortic-Valve Replacement with a Balloon-Expandable Valve in Low-Risk Patients. N. Engl. J. Med. 2019;380:1695–1705. doi: 10.1056/NEJMoa1814052. - DOI - PubMed

LinkOut - more resources