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Review
. 2023 May 17;12(5):726.
doi: 10.3390/pathogens12050726.

Bacterial Pathogens Causing Pneumonia Post Hematopoietic Stem Cell Transplant: The Chronic GVHD Population

Said Chaaban  1   2 , Andrea Zimmer  3 , Vijaya Raj Bhatt  4 , Cynthia Schmidt  5 , Ruxana T Sadikot  1   2
Affiliations
Review

Bacterial Pathogens Causing Pneumonia Post Hematopoietic Stem Cell Transplant: The Chronic GVHD Population

Said Chaaban et al. Pathogens. .

Abstract

Allogeneic stem cell transplantation is a lifesaving treatment for many malignancies. Post-transplant patients may suffer from graft versus host disease in the acute and/or the chronic form(s). Post-transplantation immune deficiency due to a variety of factors is a major cause of morbidity and mortality. Furthermore, immunosuppression can lead to alterations in host factors that predisposes these patients to infections. Although patients who receive stem cell transplant are at an increased risk of opportunistic pathogens, which include fungi and viruses, bacterial infections remain the most common cause of morbidity. Here, we review bacterial pathogens that lead to pneumonias specifically in the chronic GVHD population.

Keywords: allogeneic hematopoietic stem cell transplant; bacterial pneumonia; chronic graft versus host disease.

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Conflict of interest statement

Vijaya Raj Bhatt reports participating in Safety Monitoring Committee for Protagonist, receiving consulting fees from Imugene, research funding (institutional) from Abbvie, Pfizer, Incyte, Jazz, and National Marrow Donor Program, and drug support (institutional) from Chimerix for a trial. All other authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Flow chart diagram highlighting methodology.
See this image and copyright information in PMC

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