Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 May 5;16(5):702.
doi: 10.3390/ph16050702.

New Challenges and Prospective Applications of Three-Dimensional Bioactive Polymeric Hydrogels in Oral and Craniofacial Tissue Engineering: A Narrative Review

Gamal Abdel Nasser Atia  1 , Hany K Shalaby  2 , Naema Goda Ali  1 , Shaimaa Mohammed Morsy  1 , Mohamed Mohamady Ghobashy  3 , Hager Abdel Nasser Attia  4 , Paritosh Barai  5 , Norhan Nady  6 , Ahmad S Kodous  7 , Hasi Rani Barai  8
Affiliations
Review

New Challenges and Prospective Applications of Three-Dimensional Bioactive Polymeric Hydrogels in Oral and Craniofacial Tissue Engineering: A Narrative Review

Gamal Abdel Nasser Atia et al. Pharmaceuticals (Basel). .

Abstract

Regenerative medicine, and dentistry offers enormous potential for enhancing treatment results and has been fueled by bioengineering breakthroughs over the previous few decades. Bioengineered tissues and constructing functional structures capable of healing, maintaining, and regenerating damaged tissues and organs have had a broad influence on medicine and dentistry. Approaches for combining bioinspired materials, cells, and therapeutic chemicals are critical in stimulating tissue regeneration or as medicinal systems. Because of its capacity to maintain an unique 3D form, offer physical stability for the cells in produced tissues, and replicate the native tissues, hydrogels have been utilized as one of the most frequent tissue engineering scaffolds during the last twenty years. Hydrogels' high water content can provide an excellent conditions for cell viability as well as an architecture that mimics real tissues, bone, and cartilage. Hydrogels have been used to enable cell immobilization and growth factor application. This paper summarizes the features, structure, synthesis and production methods, uses, new challenges, and future prospects of bioactive polymeric hydrogels in dental and osseous tissue engineering of clinical, exploring, systematical and scientific applications.

Keywords: hydrogel scaffolds; polymeric hydrogels and tissues regeneration; three dimensional; tissue engineering.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Bone macroscopic and microscopic structure.
Figure 2
Figure 2
Requirement of tissue engineering scaffold.
Figure 3
Figure 3
Classification of hydrogels.
Figure 4
Figure 4
Hydrogel-assisted regeneration in dental and osseous tissues.
See this image and copyright information in PMC

References

    1. Vanholder R., Domínguez-Gil B., Busic M., Cortez-Pinto H., Craig J.C., Jager K.J., Mahillo B., Stel V.S., Valentin M.O., Zoccali C., et al. Organ donation and transplantation: A multi-stakeholder call to action. Nat. Rev. Nephrol. 2021;17:554–568. doi: 10.1038/s41581-021-00425-3. - DOI - PMC - PubMed
    1. Atala A. Advances in tissue and organ replacement. Curr. Stem. Cell. Res. Ther. 2008;3:21–31. doi: 10.2174/157488808783489435. - DOI - PubMed
    1. Mohamad M.Y., Sha’ban M.J.R. Regeneration of Human Body Parts via Tissue Engineering and Regenerative Medicine: A Brief Insight into the Technology from Islamic Perspective. Revel. Sci. 2015;5:10–17.
    1. Zhang L., Webster T.J. Nanotechnology and nanomaterials: Promises for improved tissue regeneration. Nanotoday. 2009;4:66–80. doi: 10.1016/j.nantod.2008.10.014. - DOI
    1. Jain A., Bansal R. Applications of regenerative medicine in organ transplantation. J. Pharm. Bioallied. Sci. 2015;7:188–194. doi: 10.4103/0975-7406.160013. - DOI - PMC - PubMed

LinkOut - more resources