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. 2023 Jul;28(7):508-516.
doi: 10.1111/tmi.13895. Epub 2023 May 27.

Interest of seroprevalence surveys for the epidemiological surveillance of the SARS-CoV-2 pandemic in African populations: Insights from the ARIACOV project in Benin

Parfait Houngbégnon  1 , Odilon Nouatin  1 , Anges Yadouléton  2   3 , Benjamin Hounkpatin  4 , Nadine Fievet  5 , Eloïc Atindégla  1 , Sébastien Dechavanne  5 , Emilande Guichet  6   7 , Ahidjo Ayouba  6   7 , Raphaël Pelloquin  6   7 , David Maman  8 , Guillaume Thaurignac  6   7 , Martine Peeters  6   7 , Annonciat Aviansou  4 , Salifou Sourakafou  4 , Eric Delaporte  6   7 , Achille Massougbodji  1 , Gilles Cottrell  5
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Free article

Interest of seroprevalence surveys for the epidemiological surveillance of the SARS-CoV-2 pandemic in African populations: Insights from the ARIACOV project in Benin

Parfait Houngbégnon et al. Trop Med Int Health. 2023 Jul.
Free article

Abstract

Background: Many SARS-CoV-2 seroprevalence surveys since the end of 2020 have disqualified the first misconception that Africa had been spared by the pandemic. Through the analysis of three SARS-CoV-2 seroprevalence surveys carried out in Benin as part of the ARIACOV project, we argue that the integration of epidemiological serosurveillance of the SARS-CoV-2 infection in the national surveillance packages would be of great use to refine the understanding of the COVID-19 pandemic in Africa.

Methods: We carried out three repeated cross-sectional surveys in Benin: two in Cotonou, the economic capital in March and May 2021, and one in Natitingou, a semi-rural city in the north of the country in August 2021. Total and weighted-by-age-group seroprevalences were estimated and the risk factors for SARS-CoV-2 infection were assessed by multivariate logistic regression.

Results: In Cotonou, a slight increase in overall age-standardised SARS-CoV-2 seroprevalence from 29.77% (95% CI: 23.12%-37.41%) at the first survey to 34.86% (95% CI: 31.57%-38.30%) at the second survey was observed. In Natitingou, the globally adjusted seroprevalence was 33.34% (95% CI: 27.75%-39.44%). A trend of high risk for SARS-CoV 2 seropositivity was observed in adults over 40 versus the young (less than 18 years old) during the first survey in Cotonou but no longer in the second survey.

Conclusions: Our results show that, however, rapid organisation of preventive measures aimed at breaking the chains of transmission, they were ultimately unable to prevent a wide spread of the virus in the population. Routine serological surveillance on strategic sentinel sites and/or populations could constitute a cost-effective compromise to better anticipate the onset of new waves and define public health strategies.

Keywords: SARS-CoV-2; epidemiological; seroprevalence; surveillance.

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References

REFERENCES

    1. Gouvernement de la République du Bénin. Informations coronavirus (covid-19) | Gouvernement de la République du Bénin [Internet]. [cited 2021 Nov 20]. Available from: https://www.gouv.bj/coronavirus/
    1. CDC. Coronavirus disease 2019 (COVID-19) [Internet]. Centers for Disease Control and Prevention. 2020. [cited 2021 Oct 28]. Available from: https://www.cdc.gov/coronavirus/2019-ncov/index.html
    1. Velavan TP, Meyer CG. The COVID-19 epidemic. Trop Med Int Health. 2020;25(3):278-80.
    1. Mesures de riposte-Covid-19 [Internet]. Gouvernement de la République du Bénin. [cited 2023 Apr 26]. Available from: https://www.gouv.bj/coronavirus/mesures/
    1. Nkuba AN, Makiala SM, Guichet E, Tshiminyi PM, Bazitama YM, Yambayamba MK, et al. High prevalence of anti-SARS-CoV-2 antibodies after the first wave of COVID-19 in Kinshasa, Democratic Republic of the Congo: results of a cross-sectional household-based survey. Clin Infect Dis Off Publ Infect Dis Soc Am. 2021;ciab515.

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