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. 1986 May;21(5):366-7.
doi: 10.1007/BF02535703.

Stimulation of fatty acid synthesis by 4 beta-phorbol-12-myristate-13-acetate in isolated rat hepatocytes

T Nomura, M Tachibana, H Nomura, Y Hagino

Stimulation of fatty acid synthesis by 4 beta-phorbol-12-myristate-13-acetate in isolated rat hepatocytes

T Nomura et al. Lipids. 1986 May.

Abstract

The tumor-promoting agent 4 beta-phorbol-12-myristate-13-acetate (TPA) is shown to be a potent stimulator of fatty acid synthesis in isolated rat hepatocytes. The maximal effect of TPA is seen at 10(-6) M, and the concentration for half-maximal effect is ca. 10(-8) M. Stimulation of fatty acid synthesis by TPA is shown not to require the presence of extracellular Ca++. TPA produces a significant increase in lactate and pyruvate accumulation. The possible involvement of protein kinase C in short-term regulation of fatty acid synthesis in the liver is discussed.

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