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Comment
. 2023 Jul 10;41(7):1204-1206.
doi: 10.1016/j.ccell.2023.05.013. Epub 2023 May 26.

Cholesterol atlas of tumor microenvironment provides route to improved CAR-T therapy

Adriano B Chaves-Filho  1 , Almut Schulze  2
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Cholesterol atlas of tumor microenvironment provides route to improved CAR-T therapy

Adriano B Chaves-Filho et al. Cancer Cell. .
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Abstract

Cholesterol is essential for the ability of cytotoxic T cells to eliminate cancer cells. In this issue of Cancer Cell, Yan et al. reveal how intra-tumoral cholesterol deficiency contributes to T cell exhaustion by inhibiting mTORC1 signaling. Moreover, they demonstrate that increasing cholesterol levels in chimeric antigen receptor (CAR)-T cells by blocking liver X receptor (LXR) leads to improved anti-tumor function.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

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