Mutant phosphodiesterase 3A protects the kidney from hypertension-induced damage

Anastasiia Sholokh¹, Stephan Walter², Lajos Markó³, Brandon J McMurray⁴, Daniele Yumi Sunaga-Franze⁵, Minze Xu⁶, Kerstin Zühlke⁵, Michael Russwurm⁷, Theda U P Bartolomaeus³, Reika Langanki⁵, Fatimunnisa Qadri⁵, Arnd Heuser⁵, Andreas Patzak⁶, Sofia K Forslund⁸, Sylvia Bähring⁹, Tatiana Borodina⁵, Pontus B Persson⁶, Philipp G Maass¹⁰, Michael Bader¹¹, Enno Klussmann¹²

Affiliations

¹ Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany; DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, Germany; Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
² Medizinisches Versorgungszentrum (MVZ) Nierenzentrum Limburg, Limburg, Germany.
³ DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, Germany; Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; Experimental and Clinical Research Center, a Cooperation Between the Max-Delbrück Center for Molecular Medicine in the Helmholtz Association and the Charité Universitätsmedizin Berlin, Berlin, Germany.
⁴ Genetics and Genome Biology Program, SickKids Research Institute, Toronto, Ontario, Canada.
⁵ Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.
⁶ Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
⁷ Institut für Pharmakologie und Toxikologie, Medizinische Fakultät MA N1, Ruhr-Universität Bochum, Bochum, Germany.
⁸ Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany; DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, Germany; Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; Berlin Institute of Health, Berlin, Germany; European Molecular Biology Laboratory, Structural and Computational Biology Unit, Heidelberg, Germany.
⁹ Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany; Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; Experimental and Clinical Research Center, a Cooperation Between the Max-Delbrück Center for Molecular Medicine in the Helmholtz Association and the Charité Universitätsmedizin Berlin, Berlin, Germany.
¹⁰ Genetics and Genome Biology Program, SickKids Research Institute, Toronto, Ontario, Canada; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
¹¹ Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany; DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, Germany; Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; Institute for Biology, University of Lübeck, Lübeck, Germany.
¹² Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany; DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, Germany. Electronic address: enno.klussmann@mdc-berlin.de.

PMID: 37244472
DOI: 10.1016/j.kint.2023.04.026

Mutant phosphodiesterase 3A protects the kidney from hypertension-induced damage

Anastasiia Sholokh et al. Kidney Int. 2023 Aug.

. 2023 Aug;104(2):388-393.

doi: 10.1016/j.kint.2023.04.026. Epub 2023 May 25.

Authors

Affiliations

¹ Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany; DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, Germany; Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
² Medizinisches Versorgungszentrum (MVZ) Nierenzentrum Limburg, Limburg, Germany.
³ DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, Germany; Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; Experimental and Clinical Research Center, a Cooperation Between the Max-Delbrück Center for Molecular Medicine in the Helmholtz Association and the Charité Universitätsmedizin Berlin, Berlin, Germany.
⁴ Genetics and Genome Biology Program, SickKids Research Institute, Toronto, Ontario, Canada.
⁵ Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.
⁶ Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
⁷ Institut für Pharmakologie und Toxikologie, Medizinische Fakultät MA N1, Ruhr-Universität Bochum, Bochum, Germany.
⁸ Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany; DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, Germany; Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; Berlin Institute of Health, Berlin, Germany; European Molecular Biology Laboratory, Structural and Computational Biology Unit, Heidelberg, Germany.
⁹ Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany; Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; Experimental and Clinical Research Center, a Cooperation Between the Max-Delbrück Center for Molecular Medicine in the Helmholtz Association and the Charité Universitätsmedizin Berlin, Berlin, Germany.
¹⁰ Genetics and Genome Biology Program, SickKids Research Institute, Toronto, Ontario, Canada; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
¹¹ Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany; DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, Germany; Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; Institute for Biology, University of Lübeck, Lübeck, Germany.
¹² Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany; DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, Germany. Electronic address: enno.klussmann@mdc-berlin.de.

PMID: 37244472
DOI: 10.1016/j.kint.2023.04.026

No abstract available

Keywords: amphiregulin (AREG); cyclic adenosine monophosphate (cAMP); epidermal growth factor receptor (EGFR); phosphodiesterase 3A; renoprotection.

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Mutant phosphodiesterase 3A protects the kidney from hypertension-induced damage

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Mutant phosphodiesterase 3A protects the kidney from hypertension-induced damage

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