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. 2023 Jul;49(7):1750-1761.
doi: 10.1111/jog.15665. Epub 2023 May 27.

Using dinoprostone slow release vaginal insert for cervical ripening in term-pregnancy with oligohydramnios

To Nhu Thi Ngo Nguyen  1 , Anh Dinh Bao Vuong  1 , Phuc Nhon Nguyen  1   2 , Ngoc Tran Thi Nguyen  3 , Quang Nhat Ho  4 , Quang Thanh Le  2
Affiliations

Using dinoprostone slow release vaginal insert for cervical ripening in term-pregnancy with oligohydramnios

To Nhu Thi Ngo Nguyen et al. J Obstet Gynaecol Res. 2023 Jul.

Abstract

Aims: The study purposed to evaluate the success rate of cervical ripening using dinoprostone controlled-release vaginal insert and reveal some factors relating to successful cervical ripening.

Methods: This cross-sectional study was conducted at Tu Du Hospital in Vietnam from December 2021 to August 2022. The study enrolled 200 pregnant women with gestational age ≥37 weeks diagnosed with oligohydramnios. These candidates underwent dinoprostone cervical ripening (DCR) according to the local protocol. The Bishop score ≥7 after 24 h was determined for the successful cervical ripening (SCR).

Results: In total, the success rate of DCR achieved at 57.5% and the cesarean delivery rate was 46.5%. None of the severe side-effects and complications was present. Using multivariable logistic regression, the study found that the body mass index ≥25 kg/m2 and oxytocin infusion drip related to SCR with adjusted odds ratio (aOR): 3.67 (95% confidence intervals [CI]: 1.78-7.57) and aOR: 4.68 (95% CI: 1.84-11.93), p < 0.001. Using the Kaplan-Meier curve, the present study revealed a significant difference between Bishop <3 and ≥3 following the duration time of cervical ripening, with hazard ratio: 1.38 (95% CI: 1.19-1.59), p < 0.001. The time duration of cervical ripening was not significantly different following amniotic fluid index from 3 to 5 cm.

Conclusions: Cervical ripening using a dinoprostone vaginal insert is a potentially acceptable method in term pregnancy accompanying with oligohydramnios. The probability of SCR can be predicted on a careful assessment of relative factors by obstetricians. Further studies are required to strengthen these findings.

Keywords: amniotic fluid index; cervical ripening; dinoprostone; materno-fetal outcomes; oligohydramnios; term pregnancy.

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References

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