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. 2023 Nov 18;193(10):e3052.
doi: 10.1002/vetr.3052. Epub 2023 May 28.

Faecal microbiome transplantation improves clinical signs of chronic idiopathic large bowel diarrhoea in working dogs

João C Alves  1   2   3 , Ana Santos  1 , Patrícia Jorge  1 , Ângelo Pitães  3   4
Affiliations

Faecal microbiome transplantation improves clinical signs of chronic idiopathic large bowel diarrhoea in working dogs

João C Alves et al. Vet Rec. .

Abstract

Background: Chronic diarrhoea is a common clinical sign in dogs with chronic enteropathy, and psyllium husk has been shown to improve clinical signs in affected dogs. The aim of this study was to investigate whether faecal microbiome transplant has a similar effect in alleviating clinical signs in dogs with chronic large bowel diarrhoea.

Method: Thirty large-breed working dogs with chronic large bowel diarrhoea were divided into a psyllium group (PG) and a faecal microbiome transplant group (FMTG). To the PG, 16 g/day of psyllium husk was administered for 30 days. The FMTG received faecal microbiome transplantation (FMT) once via enema. A daily log of faecal characteristics was kept, and the dogs' canine inflammatory bowel disease index (CIBDAI) and body condition scores (BCS) were determined. A Wilcoxon-Mann-Whitney test was used to compare group results. In addition, the Kaplan-Meier test was used to evaluate the occurrence rate of 1 day or more of diarrhoea and 2 days or more of diarrhoea by day 30.

Results: The sample had a mean age of 3.9 ± 2.1 years and a bodyweight of 25.3 ± 6.8 kg. The FMTG showed a more rapid onset of CIBDAI improvement but no difference in other measures. At 30 days, the FMTG showed a greater improvement in bodyweight and BCS, but no differences were observed in faecal scores, defaecation frequency and time of appearance of episodes of diarrhoea. Time played a significant positive role in the results observed across both groups (p < 0.05).

Limitations: This study did not compare the microbiomes of the dogs before and after treatment, so the role of specific types of bacteria cannot be determined.

Conclusion: Psyllium husk and FMT had similar effects in improving clinical signs of chronic large bowel diarrhoea.

Keywords: canine inflammatory bowel disease index; diarrhoea; dog; faecal microbiome transplantation.

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References

REFERENCES

    1. Volkmann M, Steiner JMM, Fosgate GTT, Zentek J, Hartmann S, Kohn B. Chronic diarrhoea in dogs-retrospective study in 136 cases. J Vet Intern Med. 2017;31(4):1043-55.
    1. Rose L, Rose J, Gosling S, Holmes M. Efficacy of a probiotic-prebiotic supplement on incidence of diarrhoea in a dog shelter: a randomized, double-blind, placebo-controlled trial. J Vet Intern Med. 2017;31(2):377-82.
    1. Nixon SL, Rose L, Muller AT. Efficacy of an orally administered anti-diarrhoeal probiotic paste (Pro-Kolin Advanced) in dogs with acute diarrhoea: a randomized, placebo-controlled, double-blinded clinical study. J Vet Intern Med. 2019;33(3):1286-94.
    1. Dandrieux JRS, Mansfield CS. Chronic enteropathy in canines: prevalence, impact and management strategies. Vet Med Res Reports. 2019;10:203-14.
    1. Lecoindre P, Gaschen FP. Chronic idiopathic large bowel diarrhoea in the dog. Vet Clin North Am Small Anim Pract. 2011;41(2):447-56.

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