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Case Reports
. 2023 Aug;35(8):e14616.
doi: 10.1111/nmo.14616. Epub 2023 May 29.

Response to Letter to the Editor

Per Cajander  1 , Taher Omari  2 , Harry Scheinin  3 , Mika Scheinin  4 , Johanna Savilampi  1
Affiliations
Case Reports

Response to Letter to the Editor

Per Cajander et al. Neurogastroenterol Motil. 2023 Aug.

Abstract

It is crucial to consider the possible influence of anesthetic agents on esophageal function testing. Dexmedetomidine has been shown to affect primary peristalsis during esophageal manometry. In the two case reports presented by Toaz et al., secondary peristalsis during FLIP panometry was also affected. This may be attributed to an alternate pharmacodynamic effect, with a transient direct α2-mediated effect on esophageal smooth muscle, associated with a high plasma concentration following bolus injection, prior to the onset of sympathetic inhibition.

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References

REFERENCES

    1. Cajander P, Omari T, Magnuson A, Scheinin H, Scheinin M, Savilampi J. Effects of dexmedetomidine on pharyngeal swallowing and esophageal motility-a double-blind randomized cross-over study in healthy volunteers. Neurogastroenterol Motil. 2022;35:e14501.
    1. Yadlapati R, Kahrilas PJ, Fox MR, et al. Esophageal motility disorders on high-resolution manometry: Chicago classification version 4.0(©). Neurogastroenterol Motil. 2021;33(1):e14058.
    1. Cajander P, Omari T, Cock C, Magnuson A, Scheinin M, Savilampi J. Effects of remifentanil on pharyngeal swallowing and esophageal motility: no impact of different bolus volumes and partial antagonism by methylnaltrexone. Am J Physiol Gastrointest Liver Physiol. 2021;321(4):G367-G377.
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    1. Bloor BC, Ward DS, Belleville JP, Maze M. Effects of intravenous dexmedetomidine in humans II. Hemodynamic changes. Anesthesiology. 1992;77(6):1134-1142.

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