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. 2023 May 1;24(5):1731-1735.
doi: 10.31557/APJCP.2023.24.5.1731.

Estrogen, Progesterone and Androgen Receptor in Primary and Recurrent Pleomorphic Salivary Adenomas

Bassel Tarakji  1 , Faisal Mehsen Alali  1
Affiliations

Estrogen, Progesterone and Androgen Receptor in Primary and Recurrent Pleomorphic Salivary Adenomas

Bassel Tarakji et al. Asian Pac J Cancer Prev. .

Abstract

Objective: Our study aimed to characterize alteration in the immunohistochemical expression of estrogen, progesterone and androgen receptor in the tumour cells of primary pleomorphic adenomas and recurrent pleomorphic adenomas.

Methods: A retrospective study of data including 30 cases of primary pleomorphic adenomas (PA) without recurrences and 15 cases of recurrent pleomorphic adenomas were examined (RPA). RPA included 8 males and 7 females. Immunohistochemical expression of estrogen, progesterone and androgen receptor was examined in the selected cases. The percentage of slides was semi-quantitatively assessed by two independent observers and scores were given. The statistical analysis included the use of descriptive statistics and proportional frequencies.

Results: AR expression was identified in 12 (40. %) out of 30 cases of (PA) pleomorphic adenomas and 7 of 15 cases recurrent pleomorphic adenomas (RPA) (46 %). The results showed that ER and PR expression were negative in PA and RPA.

Conclusion: Androgen receptors might have role in pathogenesis of PA and RPA. Estrogen and progesterone receptors have no role in development of recurrent pleomorphic salivary adenoma.

Keywords: Expression of Estrogen; progesterone and androgen receptor; recurrent pleomorphic salivary adenoma.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Shows AR Positive Expression in Recurrent Pleomorphic Adenoma
Figure 2
Figure 2
Shows ER Negative Expression in Recurrent Pleomorphic Adenoma
Figure 3
Figure 3
Shows PR Negative Expression in Recurrent Pleomorphic Adenoma
Figure 4
Figure 4
Showing Extra-Capsular Extension in Pleomorphic Salivary Adenoma
Figure 5
Figure 5
Islands and Strands in a Myxoid Stroma in Pleomorphic Salivary Adenoma
See this image and copyright information in PMC

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