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. 2023 May 1;24(5):1789-1795.
doi: 10.31557/APJCP.2023.24.5.1789.

Cytogenetic Characteristics of de novo Acute Myeloid Leukemia in Southern Vietnam

Lai Thi Thanh Thao  1   2 , Chau Thuy Ha  3 , Nguyen Thi Thanh Ha  4 , Suzanne Monivong Cheanh Beaupha  1   2 , Huynh Nghia  1   3 , Tran Thanh Tung  2 , Nguyen Truong Son  2 , Nguyen Tan Binh  3 , Phu Chi Dung  3 , Hoang Anh Vu  5 , Phan Thi Xinh  1   3
Affiliations

Cytogenetic Characteristics of de novo Acute Myeloid Leukemia in Southern Vietnam

Lai Thi Thanh Thao et al. Asian Pac J Cancer Prev. .

Abstract

Background: The cytogenetic characteristics are important factors for risk stratification at diagnosis of acute myeloid leukemia (AML); however, cytogenetic profile of Vietnamese patients with AML remains undetermined. In this study, we present the chromosomal data of de novo AML patients in Southern Vietnam.

Methods: We performed cytogenetic testing for 336 AML patients using G banding. If the patients had suspected abnormalities, fluorescence in situ hybridization with probes of inv(3)(q21q26)/t(3;3)(q21;q26), 5q31, 7q31, t(8;21)(q21.3;q22), 11q23, t(15;17)(q24;q21), inv(16)(p13q22)/t(16;16)(p13;q22)were analyzed. Patients without above aberrations or with normal karyotype were tested by fluorescence in situ hybridization using probe 11q23.

Results: We found that the median age was 39 years. According to French - American - British classification, AML-M2 is the most frequent type with 35.1%. Chromosomal abnormalities were detected in 208 cases, accounting for 61.9%. Among structural abnormalities, t(15;17) was the most common (19.6%), followed by t(8;21) and inv (16)/t(16;16) in 10.1% and 6.2%, respectively. In perspective of chromosomal numerical abnornmalities, loss of sex chromosomes are the most common (7.7%), followed by +8 in 6.8%, -7/del(7q) in 4.4%, +21 in 3.9% and -5/del (5q) in 2.1%. The prevalence of addditional cytogenetic aberrations accompanying with t(8;21) and inv(16)/t(16;16) were 82.4% and 52.4%, repectively. None of +8 cases was associated with t(8;21). Regarding cytogenetic risk assessment according to European Leukemia Net 2017, there were 121 (36%) patients in favorable-risk, 180 (53.6%) in intermediate-risk and 35 (10.4%) in adverse-risk group.

Conclusion: In conclusion, this is the first comprehensive cytogenetic profile of Vietnamese patients diagnosed with de novo AML, which helps clinical doctors in prognostic classification for AML patients in Southern Vietnam.

Keywords: Vietnam; acute myeloid leukemia; cytogenetics; karyotyping.

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Conflict of interest statement

The authors have no conflicts of interest to declare.

References

    1. Abuhelwa Z, Al Shaer Q, Taha S, et al. Characteristics of de novo acute myeloid leukemia patients in Palestine: experience of An-Najah National University Hospital. Asian Pac J Cancer Prev. 2017;18:2459. - PMC - PubMed
    1. Alrajeh AI, Abalkhail H, Khalil SH. Cytogenetics and molecular markers of acute myeloid leukemia from a tertiary care center in Saudi Arabia. J Appl Hematol. 2017;8:68.
    1. Appelbaum FR, Kopecky KJ, Tallman MS, et al. The clinical spectrum of adult acute myeloid leukaemia associated with core binding factor translocations. Br J Haematol. 2006;135:165–73. - PubMed
    1. Byrd JC, Mrózek K, Dodge RK, et al. Pretreatment cytogenetic abnormalities are predictive of induction success, cumulative incidence of relapse, and overall survival in adult patients with de novo acute myeloid leukemia: results from Cancer and Leukemia Group B (CALGB 8461) Presented in part at the 43rd annual meeting of the American Society of Hematology, Orlando, FL, December 10, 2001, and published in bstract form 59. Blood Am J Hematol. 2002;100:4325–36. - PubMed
    1. Cheng Y, Wang Y, Wang H, et al. Cytogenetic profile of de novo acute myeloid leukemia: a study based on 1432 patients in a single institution of China. Leukemia. 2009;23:1801–6. - PubMed

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