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Review
. 2023 Jun;29(3):252-257.
doi: 10.1007/s13365-023-01138-y. Epub 2023 May 29.

Multi-functional auto-fluorescent nanogels for theranostics

Arti Vashist  1   2 , Andrea D Raymond  3   4 , Prem Chapagain  5 , Atul Vashist  6 , Adriana Yndart Arias  3   4 , Nagesh Kolishetti  3   4 , Madhavan Nair  3   4
Affiliations
Review

Multi-functional auto-fluorescent nanogels for theranostics

Arti Vashist et al. J Neurovirol. 2023 Jun.

Abstract

Here in the present article, the state of art for nanotechnology-enabled nanogel theranostics and the upcoming concepts in nanogel-based therapeutics are summarized. The benefits, innovation, and prospects of nanogel technology are also briefly presented.

Keywords: Cancer; Imaging; Infectious diseases; Micro/nanogel; Neurological disorders; Theranostics; Therapeutics.

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Conflict of interest statement

US patent for “Micro/Nano Magnetic Hydrogels with Autofluorescence for Therapeutic and Diagnostic Applications” (US 10,344,100) 2019 with Arti Vashist, Ajeet K Kaushik, Madhavan P Nair as inventors. US non-provisional patent application for “Biotherapy for Viral infections using Biopolymer based Micro/Nanogels.” (US 17/615,940) 2022, with Madhavan P Nair, Arti Vashist, Andrea Raymond as inventors.

Figures

Fig. 1
Fig. 1
Nanogels for theranostics for various diseases. “Created with BioRender.com”
Fig. 2
Fig. 2
Fluorescence properties of the nanogels at various concentrations using flow cytometer. A The mean intensity values of the single-particle population for each channel at an excitation wavelength of 405 nm. B Images acquired for the presence of fluorescence for and aggregated and single particle in each channel at an excitation wavelength of 405 nm. Copyright permission from reference Vashist et al. (2020) under Creative Commons Attribution (“CC BY”) license
Fig. 3
Fig. 3
Low nanogel stiffness favors nanogel transcytosis across an in vitro blood–brain barrier. Copyright from reference Ribovski et al.  Elsevier under Creative Commons CC-BY license
See this image and copyright information in PMC

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