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Review
. 2023 May;54(3):475-481.
doi: 10.12182/20230560207.

[Latest Findings on the Mechanism of the Interaction Between Multiple Myeloma Cells and Bone Marrow Microenvironment]

[Article in Chinese]
Ni-Han He  1 , Wen Zhou  1
Affiliations
Review

[Latest Findings on the Mechanism of the Interaction Between Multiple Myeloma Cells and Bone Marrow Microenvironment]

[Article in Chinese]
Ni-Han He et al. Sichuan Da Xue Xue Bao Yi Xue Ban. 2023 May.

Abstract
in English, Chinese

Multiple myeloma (MM) is a hematologic malignancy of terminally differentiated plasma cells. The mechanisms of the pathogenesis and progression of MM include genetic abnormalities of the MM cells and the interaction between MM cells and bone marrow microenvironment (BMME). MM cells start malignant proliferation in BMME and contribute to the pathogenesis and progression of MM through direct or indirect interactions between cells and the extracellular matrix. Exploring the mechanism of interaction between MM cells and the microenvironment is crucial to improving our understanding of the pathogenesis and progression of MM and early diagnosis and treatment. In addition, the metabolic reprogramming of tumors is one of the key issues of oncology research. Herein, we summarized published findings on the the altered metabolic reprogramming of MM and the characteristics of MM metabolic-microbial interactions in order to gain an in-depth understanding of MM pathogenesis and progression and drug resistance mechanisms, and ultimately to explore for new strategies for MM treatment.

多发性骨髓瘤（multiple myeloma, MM）是浆细胞来源的血液系统恶性肿瘤，其发生发展机制主要包括肿瘤细胞遗传学异常和细胞与骨髓微环境（bone marrow microenvironment, BMME）互作。MM细胞在BMME内恶性增殖，通过细胞与细胞外基质的直接或间接互作，促进MM的发生发展。探讨MM细胞与微环境的互作机制，对阐明MM发生发展机制及早诊和治疗有着重要意义。肿瘤的代谢重编程是肿瘤学研究的重点之一。本文总结出微环境中MM的代谢重编程改变和MM代谢与微生物互作的特征，以便于深入了解MM的发生发展及耐药性机制，最终达到挖掘MM治疗的新策略之目的。

Keywords: Bone marrow microenvironment; Clonal evolution; Metabolic microenvironment; Multiple myeloma.

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Conflict of interest statement

利益冲突 所有作者均声明不存在利益冲突

Figures

图 1
图 1
The interaction between MM cells andthe microenvironment MM肿瘤细胞与微环境的相互作用
See this image and copyright information in PMC

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References

    1. LANDGREN O, HULTCRANTZ M, DIAMOND B, et al Safety and effectiveness of weekly carfilzomib, lenalidomide, dexamethasone, and daratumumab combination therapy for patients with newly diagnosed multiple myeloma: the MANHATTAN Nonrandomized Clinical Trial. JAMA Oncol. 2021;7(6):862–868. doi: 10.1001/jamaoncol.2021.0611. - DOI - PMC - PubMed
    1. ZANG M, GUO J, LIU L, et al Cdc37 suppression induces plasma cell immaturation and bortezomib resistance in multiple myeloma via Xbp1s. Oncogenesis. 2020;9(3):31. doi: 10.1038/s41389-020-0216-1. - DOI - PMC - PubMed
    1. WALKER B A, MAVROMMATIS K, WARDELL C P, et al A high-risk, double-hit, group of newly diagnosed myeloma identified by genomic analysis. Leukemia. 2019;33(1):159–170. doi: 10.1038/s41375-018-0196-8. - DOI - PMC - PubMed
    1. LI N, JOHNSON D C, WEINHOLD N, et al Multiple myeloma risk variant at 7p15.3 creates an IRF4-binding site and interferes with CDCA7L expression. Nat Commun. 2016;7:13656. doi: 10.1038/ncomms13656. - DOI - PMC - PubMed
    1. MAURA F, BOLLI N, ANGELOPOULOS N, et al Genomic landscape and chronological reconstruction of driver events in multiple myeloma. Nat Commun. 2019;10(1):3835. doi: 10.1038/s41467-019-11680-1. - DOI - PMC - PubMed

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