Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Sep;29(9):2413-2429.
doi: 10.1111/cns.14276. Epub 2023 May 29.

Does resveratrol improve cognition in humans? A scientometric study to an in-depth review

Wenling Tu  1 , Meiying Song  1 , Xiang Fan  1
Affiliations
Review

Does resveratrol improve cognition in humans? A scientometric study to an in-depth review

Wenling Tu et al. CNS Neurosci Ther. 2023 Sep.

Abstract

Aim: In order to understand the different processes and mechanisms of cognitive function and resveratrol (RES) as an active participant in pathophysiological events that affect cognitive function.

Methods: First, the Web of Science (core collection) was selected as the data source. To ensure the comprehensiveness and accuracy of the search data, the index was selected as "SCI-EXPANDED", and the search formula was TS = resveratrol AND TS = ("cognitive" OR "memory" OR "cognition" OR "mood"). Next, details of authors, keywords, journals, countries, institutions, references, and more were analyzed by CiteSpace and VOSviewer software. Finally, we explored the mechanism by which RES could improve cognitive impairment, that involves healthy young adults, healthy elderly, post-menopausal women, and diseases involving Alzheimer's disease (AD), diabetes-related cognitive impairment, mental illness, post-stroke cognitive impairment, and neonatal hypoxic-ischemic injury.

Results: 287 valid papers were obtained. The scientometric results demonstrated 287 papers used in this study came from 1601 authors from 443 organizations in 38 countries, published in 169 journals, and cited 13,680 literatures from 2431 journals. Depression, AD, cerebral ischemia, diabetic cognitive impairment, and cognitive function in the elderly are all keywords of the co-occurrence network.

Conclusion: This study supports the hypothesis that chronic RES intake may positively affect brain function. But it has become challenging to determine the optimal dose, time and duration of RES and improve the bioavailability of RES, which many researchers need to overcome.

Keywords: Clinical application; cognitive function; resveratrol; scientometric study.

PubMed Disclaimer

Conflict of interest statement

All authors declare there is no potential conflicts of interest include employment, consultancies, stock ownership, honoraria, paid expert testimony, patent applications/registrations, and grants or other funding.

Figures

FIGURE 1
FIGURE 1
The flow chart of study of RES on cognitive function.
FIGURE 2
FIGURE 2
Scientometric study of resveratrol on cognitive impairment. (A) Distribution of publications from 2008 to 2022. (B) The cooperation relationships of countries or regions. (C) Institutions co‐occurrence network. (D) Keyword co‐occurrence diagram from 2008 to 2022.
FIGURE 3
FIGURE 3
Scheme illustrating the role of RES on cognitive function in healthy young adults.
FIGURE 4
FIGURE 4
Scheme illustrating the role of RES on cognitive function in healthy older adults by figdraw.
FIGURE 5
FIGURE 5
Scheme illustrating the role of RES on cognitive function in post‐menopausal women by figdraw.
FIGURE 6
FIGURE 6
Scheme illustrating the role of RES on cognitive impairment in AD by figdraw.
FIGURE 7
FIGURE 7
Presumed causes of memory impairment in patients with diabetes by figdraw.
FIGURE 8
FIGURE 8
Scheme illustrating the role of RES on cognitive impairment in mental illness by governing the ERK‐CREB signaling pathway by figdraw.
FIGURE 9
FIGURE 9
Scheme illustrating the role of RES on cognitive impairment in post‐stroke cognitive disorder by governing the JAK/ERK/STAT signaling pathway.
FIGURE. 10
FIGURE. 10
Scheme illustrating the role of RES on cognitive impairment in neonatal HI injury by figdraw.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Knight MJ, Baune BT. Cognitive dysfunction in major depressive disorder. Curr Opin Psychiatry. 2018;31:26‐31. - PubMed
    1. Jessen F, Amariglio RE, Buckley RF, et al. The characterisation of subjective cognitive decline. Lancet Neurol. 2020;19:271‐278. - PMC - PubMed
    1. MacQueen GM, Memedovich KA. Cognitive dysfunction in major depression and bipolar disorder: Assessment and treatment options. Psychiatry Clin Neurosci. 2017;71:18‐27. - PubMed
    1. Power MC, Mormino E, Soldan A, et al. Combined neuropathological pathways account for age‐related risk of dementia. Ann Neurol. 2018;84:10‐22. - PMC - PubMed
    1. Horsburgh K, Wardlaw JM, van Agtmael T, et al. Small vessels, dementia and chronic diseases – molecular mechanisms and pathophysiology. Clin Sci. 2018;132:851‐868. - PMC - PubMed

Publication types