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. 2023 Oct;280(10):4501-4507.
doi: 10.1007/s00405-023-08028-3. Epub 2023 May 30.

Impact of extended sinus surgery on allograft infection, allograft function and overall survival in cystic fibrosis lung transplant recipients

Manuel Meier  1   2 , Macé M Schuurmans  3   2 , Domenic Vital  4 , Ilhan Inci  5   6 , David Holzman  1   2 , Michael B Soyka  7   8
Affiliations

Impact of extended sinus surgery on allograft infection, allograft function and overall survival in cystic fibrosis lung transplant recipients

Manuel Meier et al. Eur Arch Otorhinolaryngol. 2023 Oct.

Abstract

Background: Studies investigating the impact of sinus surgery for cystic fibrosis (CF) patients performed early after lung transplantation (Ltx) are scarce. Recent studies evaluating frequency of respiratory infections and graft outcomes are not available.

Objectives/hypothesis: To determine whether there is a difference in allograft infection, allograft function and overall survival among CF lung transplant recipients with and without concomitant sinus surgery.

Study design: Retrospective single-center study.

Methods: We examined 71 CF patients who underwent Ltx between 2009 and 2019 at our center. Fifty-nine patients had sinus surgery before or/and after transplantation and twelve did not undergo sinus surgery. We assessed the survival, the diagnosis of chronic allograft dysfunction (CLAD) and all elevated (> 5 mg/l) c-reactive protein episodes during the observed period. The infectious events of the upper and lower airways were categorized in mild infections (5-15 mg/l CRP) and severe infections (> 15 mg/l CRP).

Results: There was no difference in the long-time overall survival (p = 0.87) and no benefit in the short-term survival at 4 year post-transplant (p = 0.29) in both groups. There was no difference in both groups concerning CLAD diagnosis (p = 0.92). The incidence of severe upper and lower airway infections (CRP > 15 mg/l) was significantly decreased in the sinus surgery group (p = 0.015), whereas in mild infections there was a trend to decreased infections in the sinus surgery group (p = 0.056).

Conclusions: CF patients undergoing Ltx benefit from extended endoscopic sinus surgery (eESS) in terms of frequency of severe infectious events of the upper and lower airways. There was no difference in overall survival and frequency of CLAD in the two groups.

Keywords: Chronic allograft dysfunction; Cystic fibrosis; Extended sinus surgery; Infectious events; Lung transplantation.

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Figures

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Fig. 1
Overall survival
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CLAD-free survival
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Mild and severe infection episodes
See this image and copyright information in PMC

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