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Review
. 2023 May 12:15:1174644.
doi: 10.3389/fnagi.2023.1174644. eCollection 2023.

Biomarkers of delirium risk in older adults: a systematic review and meta-analysis

Lucía Lozano-Vicario  1 , Antonio García-Hermoso  2 , Bernardo Abel Cedeno-Veloz  1 , Joaquín Fernández-Irigoyen  3 , Enrique Santamaría  3 , Román Romero-Ortuno  4 , Fabricio Zambom-Ferraresi  2   5 , Mikel L Sáez de Asteasu  2 , Ángel Javier Muñoz-Vázquez  6 , Mikel Izquierdo  2   5 , Nicolás Martínez-Velilla  1   2   5
Affiliations
Review

Biomarkers of delirium risk in older adults: a systematic review and meta-analysis

Lucía Lozano-Vicario et al. Front Aging Neurosci. .

Abstract

Delirium is a neuropsychiatric syndrome associated with increased morbidity and mortality in older patients. The aim of this study was to review predictive biomarkers of delirium in older patients to gain insights into the pathophysiology of this syndrome and provide guidance for future studies. Two authors independently and systematically searched MEDLINE, Embase, Cochrane Library, Web of Science and Scopus databases up to August 2021. A total of 32 studies were included. Only 6 studies were eligible for the meta-analysis, pooled results showed a significant increase in some serum biomarkers (C-reactive protein [CRP], tumour necrosis factor alpha [TNF-α] and interleukin-6 [IL-6]) among patients with delirium (odds ratio = 1.88, 95% CI 1.01 to 1.637; I2 = 76.75%). Although current evidence does not favour the use of any particular biomarker, serum CRP, TNF-α, and IL-6 were the most consistent biomarkers of delirium in older patients.

Keywords: biomarkers; cognitive impairment; delirium; neuroinflammation; older people.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Flowchart.
Figure 2
Figure 2
Forest plot.
Figure 3
Figure 3
Recommendations for future research in delirium biomarkers.
See this image and copyright information in PMC

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