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Case Reports
. 2023 Apr 25;15(4):e38124.
doi: 10.7759/cureus.38124. eCollection 2023 Apr.

Possible Ambiguity in Interpretation Between Immunoglobulin G4-Related Disease (IgG4-RD) and Sarcoidosis in a Post-COVID-19 Pandemic

Rajesh Gurunathan  1   2 , Pavithra Dhanasekaran  3 , Dedeepiya Devaprasad  2 , Sheba Sk Jacob  4 , Babu K Abraham  2
Affiliations
Case Reports

Possible Ambiguity in Interpretation Between Immunoglobulin G4-Related Disease (IgG4-RD) and Sarcoidosis in a Post-COVID-19 Pandemic

Rajesh Gurunathan et al. Cureus. .

Abstract

A 36-year-old lady presented with fever, cough, maculopapular rash, painless sialadenitis, episcleritis, and arthralgia of more than 10 months, occurring in episodes since she tested positive for COVID-19 in 2020. Her symptoms were well controlled with corticosteroid and immunosuppressant therapy. Her clinical presentation and findings on bronchoscopy resembled that of sarcoidosis. However, the bronchial biopsy histopathology ruled out sarcoidosis. An increased serum immunoglobulin G4 level and its possible association with COVID-19 raises the question of whether the possibility of immunoglobulin G4-related disease (IgG4-RD) could be entertained.

Keywords: elevated serum igg4; igg4 and covid 19 infection; igg4- related disorders; sarcoidosis “like; steroid responsive.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Maculopapular rash involving both lower limbs.
Figure 2
Figure 2. Maculopapular rash involving left leg.
Figure 3
Figure 3. Episcleritis involving the left eye.
See this image and copyright information in PMC

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