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Comment
. 2023 Nov;33(11):817-818.
doi: 10.1038/s41422-023-00829-9.

Accelerated transcriptional elongation during aging impairs longevity

Alexander Tyshkovskiy  1 , Sirui Zhang  1 , Vadim N Gladyshev  2   3
Affiliations
Comment

Accelerated transcriptional elongation during aging impairs longevity

Alexander Tyshkovskiy et al. Cell Res. 2023 Nov.
No abstract available

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Figures

Fig. 1
Fig. 1. Association of the transcriptional elongation rate with aging and longevity.
RNA Pol II elongation speed is elevated in old and senescent cells, presumably due to reduced nucleosome occupancy partially driven by the decreased level of histones. Higher rate of elongation is associated with flatter intron RNA read gradient and accumulation of splicing errors. Mutated roundworms and fruit flies with slower elongation rate exhibit fewer splicing errors and increased lifespan.
See this image and copyright information in PMC

Comment on

  • Ageing-associated changes in transcriptional elongation influence longevity.
    Debès C, Papadakis A, Grönke S, Karalay Ö, Tain LS, Mizi A, Nakamura S, Hahn O, Weigelt C, Josipovic N, Zirkel A, Brusius I, Sofiadis K, Lamprousi M, Lu YX, Huang W, Esmaillie R, Kubacki T, Späth MR, Schermer B, Benzing T, Müller RU, Antebi A, Partridge L, Papantonis A, Beyer A. Debès C, et al. Nature. 2023 Apr;616(7958):814-821. doi: 10.1038/s41586-023-05922-y. Epub 2023 Apr 12. Nature. 2023. PMID: 37046086 Free PMC article.

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