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Comment
. 2023 Jul;22(7):535.
doi: 10.1038/d41573-023-00086-w.

Inhibiting Sec61-mediated protein translocation

Sarah Crunkhorn
Comment

Inhibiting Sec61-mediated protein translocation

Sarah Crunkhorn. Nat Rev Drug Discov. 2023 Jul.
No abstract available

PubMed Disclaimer

Comment on

  • A common mechanism of Sec61 translocon inhibition by small molecules.
    Itskanov S, Wang L, Junne T, Sherriff R, Xiao L, Blanchard N, Shi WQ, Forsyth C, Hoepfner D, Spiess M, Park E. Itskanov S, et al. Nat Chem Biol. 2023 Sep;19(9):1063-1071. doi: 10.1038/s41589-023-01337-y. Epub 2023 May 11. Nat Chem Biol. 2023. PMID: 37169959 Free PMC article.
  • Signal peptide mimicry primes Sec61 for client-selective inhibition.
    Rehan S, Tranter D, Sharp PP, Craven GB, Lowe E, Anderl JL, Muchamuel T, Abrishami V, Kuivanen S, Wenzell NA, Jennings A, Kalyanaraman C, Strandin T, Javanainen M, Vapalahti O, Jacobson MP, McMinn D, Kirk CJ, Huiskonen JT, Taunton J, Paavilainen VO. Rehan S, et al. Nat Chem Biol. 2023 Sep;19(9):1054-1062. doi: 10.1038/s41589-023-01326-1. Epub 2023 May 11. Nat Chem Biol. 2023. PMID: 37169961 Free PMC article.

References

    1. Itskanov, S. et al. A common mechanism of Sec61 translocon inhibition by small molecules. Nat. Chem. Biol. https://doi.org/10.1038/s41589-023-01337-y (2023)
    1. Rehan, S. et al. Signal peptide mimicry primes Sec61 for client-selective inhibition. Nat. Chem. Biol. https://doi.org/10.1038/s41589-023-01326-1 (2023)

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