Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2024 Feb;112(2):153-173.
doi: 10.1111/ejh.14014. Epub 2023 May 31.

Mesenchymal stromal cells and CAR-T cells in regenerative medicine: The homing procedure and their effective parameters

Hanieh Kolahi Azar  1   2 , Aylar Imanpour  2 , Hanieh Rezaee  2   3 , Fatemeh Ezzatifar  2   4   5 , Zeinab Zarei-Behjani  2   6 , Mohammadreza Rostami  7   8 , Mahmoud Azami  2   9 , Nima Behestizadeh  2   9 , Nima Rezaei  10   11   12
Affiliations
Review

Mesenchymal stromal cells and CAR-T cells in regenerative medicine: The homing procedure and their effective parameters

Hanieh Kolahi Azar et al. Eur J Haematol. 2024 Feb.

Abstract

Mesenchymal stromal cells (MSCs) and chimeric antigen receptor (CAR)-T cells are two core elements in cell therapy procedures. MSCs have significant immunomodulatory effects that alleviate inflammation in the tissue regeneration process, while administration of specific chemokines and adhesive molecules would primarily facilitate CAR-T cell trafficking into solid tumors. Multiple parameters affect cell homing, including the recipient's age, the number of cell passages, proper cell culture, and the delivery method. In addition, several chemokines are involved in the tumor microenvironment, affecting the homing procedure. This review discusses parameters that improve the efficiency of cell homing and significant cell therapy challenges. Emerging comprehensive mechanistic strategies such as non-systemic and systemic homing that revealed a significant role in cell therapy remodeling were also reviewed. Finally, the primary implications for the development of combination therapies that incorporate both MSCs and CAR-T cells for cancer treatment were discussed.

Keywords: CAR-T cells; cell homing; cell therapy; mesenchymal stromal cells; regenerative medicine.

PubMed Disclaimer

References

REFERENCES

    1. He XT, Wang J, Li X, Yin Y, Sun HH, Chen FM. The critical role of cell homing in cytotherapeutics and regenerative medicine. Adv Ther. 2019;2(1):1800098.
    1. Liesveld JL, Sharma N, Aljitawi OS. Stem cell homing: from physiology to therapeutics. Stem Cells. 2020;38(10):1241-1253.
    1. Singh JP. Enabling Technologies for Homing and Engraftment of Cells for Therapeutic Applications. American College of Cardiology Foundation; 2009.
    1. Wei X, Yang X, Han Z-P, Qu F-F, Shao L, Shi Y-F. Mesenchymal stem cells: a new trend for cell therapy. Acta Pharmacol Sin. 2013;34(6):747-754.
    1. Mohanty R, Chowdhury CR, Arega S, Sen P, Ganguly P, Ganguly N. CAR T cell therapy: a new era for cancer treatment. Oncol Rep. 2019;42(6):2183-2195.

LinkOut - more resources