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. 2023 Sep 1;50(9):591-594.
doi: 10.1097/OLQ.0000000000001838. Epub 2023 May 28.

Case Series of Stillbirths Due to Syphilis in Edmonton, Alberta, Canada

Joan L Robinson  1 , Anna Donovan  1 , Jennifer Gratrix  2 , Petra Smyczek  2 , Alena Tse-Chang  1
Affiliations

Case Series of Stillbirths Due to Syphilis in Edmonton, Alberta, Canada

Joan L Robinson et al. Sex Transm Dis. .

Abstract

Background: Data on the incidence and characteristics of stillbirths attributed to congenital syphilis were collected.

Methods: We extracted data on stillbirths in the Edmonton Zone on January 1, 2015, through June 30, 2021, born to persons diagnosed with infectious syphilis (primary, secondary, early latent, or early neurosyphilis) during pregnancy or at the time of delivery.

Results: Of 314 infants documented to be exposed to infectious syphilis during gestation, 16 (5.1%) were stillborn. Three of the 16 females with stillbirths were diagnosed with syphilis during pregnancy but not treated, 12 were diagnosed only at the time of stillbirth (1 of whom was treated early in pregnancy and presumably reinfected), and 1 had a stillbirth in the week after one dose of benzathine penicillin G.

Conclusions: Stillbirths due to congenital syphilis were all due to failure to treat syphilis in pregnancy. Innovative strategies to prevent syphilis in the community and to reach those experiencing barriers to care are urgently required to not miss opportunities to diagnose and treat syphilis as early as possible during pregnancy.

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Conflict of interest statement

Conflict of Interest and Sources of Funding: None declared.

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