Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Aug;42(8):1031-1036.
doi: 10.1007/s10096-023-04628-3. Epub 2023 May 31.

Development and evaluation of automated synovial fluid total cell count on an Iris iQ® 200 for identifying patients at risk of septic arthritis

L Ruffier d'Epenoux  1   2 , E Fayoux  1 , P Bémer  1 , V Biering  1 , A Bonte  1 , Y Elaiba  1 , M Robert  1 , A Guillouzouic  1 , E Tessier  1 , E Persyn  1 , S Corvec  3   4
Affiliations

Development and evaluation of automated synovial fluid total cell count on an Iris iQ® 200 for identifying patients at risk of septic arthritis

L Ruffier d'Epenoux et al. Eur J Clin Microbiol Infect Dis. 2023 Aug.

Abstract

Septic arthritis is a diagnostic emergency. The white blood cell (WBC) count, in synovial fluid (SF), can guide the diagnosis. From November 2021 to November 2022, we included 350 SF. The WBC count was performed with the Iris iQ® 200 compared with the manual method. Automated and manual counts displayed good correlation. However, a Bland Altman plot demonstrates a higher percentage difference at higher WBC counts. The use of Iris iQ® 200 for SF analysis enables a rapid and accurate assessment for WBC count. Its implementation would advantageously replace the long and tedious optical analysis in daily routine.

Keywords: Automated cell analysis; SF WBC count; Synovial fluid.

PubMed Disclaimer

References

    1. Abram SGF, Alvand A, Judge A, Beard DJ, Price AJ (2020) Mortality and adverse joint outcomes following septic arthritis of the native knee: a longitudinal cohort study of patients receiving arthroscopic washout. Lancet Infect Dis Mars 20(3):341–349 - DOI
    1. Ravn C, Neyt J, Benito N, Abreu MA, Achermann Y, Bozhkova S et al (2023) Guideline for management of septic arthritis in native joints (SANJO). J Bone Jt Infect 8(1):29–37 - DOI - PubMed - PMC
    1. Tuuminen T, Lounamo K, Leirisalo-Repo M (2013) A review of serological tests to assist diagnosis of reactive arthritis: critical appraisal on methodologies. Front Immunol 4:418 - DOI - PubMed - PMC
    1. Tiwari V, Bergman MJ (2023) Viral arthritis. StatPearls Publishing, StatPearls. Treasure Island (FL)
    1. Couderc M, Pereira B, Mathieu S, Schmidt J, Lesens O, Bonnet R et al (2015) Predictive value of the usual clinical signs and laboratory tests in the diagnosis of septic arthritis. Can J Emerg Med 17(4):403–410 - DOI

LinkOut - more resources